SKL27969, an oral selective PRMT5 inhibitor, sensitizes the effect of DNA-damaging agents in preclinical models of multiple solid tumors

被引：0
|
作者：
Moon, Mijin
Shin, Yongje
Ki, Soyoung
Na, Jungtae
Lee, Ho Yeon
Koh, Ilkyoo
Hong, Beomjin
Yun, Jiyeon
Laramy, Janice
Vashi, Vijaykumar
Park, Sook-Kyung
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-6276
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
6276
引用
收藏
页数：2
相关论文
共 2 条
  • [1] DISCOVERY AND PHARMACOLOGICAL CHARACTERIZATION OF SKL27969, A NOVEL BRAINPENETRATING PRMT5 INHIBITOR WITH STRONG ANTITUMOR ACTIVITY, IN GLIOBLASTOMA AND BRAIN METASTASIS PRECLINICAL MODELS
    Moon, Mijin
    Shin, Yongje
    Lee, Ho Yeon
    Hong, Beomjin
    Kim, Jinhee
    Lee, Jun
    Laramy, Janice K.
    Vashi, Vijaykumar
    Park, Sook-Kyung
    NEURO-ONCOLOGY, 2022, 24 : 233 - 234
  • [2] TUMOR PHARMACOKINETICS AND PHARMACODYNAMICS IN PATIENT-DERIVED XENOGRAFT MODELS OF GLIOBLASTOMA TREATED WITH THE PRMT5 INHIBITOR SKL27969
    Tien, An-Chi
    Margaryan, Tigran
    Molloy, Jennifer
    McNamara, James
    Knight, William
    Hon, Raymond
    Opachich, Zorana
    Melendez, Ernesto Luna
    Elliott, Mackenna
    White, Connor
    Sanai, Nader
    Tovmasyan, Artak
    Mehta, Shwetal
    NEURO-ONCOLOGY, 2023, 25
1