Large-cell Neuroendocrine Carcinoma of the Lung with Carcinoid Syndrome

被引：1
|
作者：
Yamamoto, Makoto [1 ]
Ito, Renma [1 ]
Tsujibata, Akihiko [2 ]
Morita, Hiroko [1 ]
Yoneda, Taro [1 ]
Matano, Yutaka [1 ]
Higashikata, Toshinori [1 ]
机构：
[1] Komatsu Municipal Hosp, Dept Internal Med, Komatsu, Japan
[2] Komatsu Municipal Hosp, Dept Pathol, Komatsu, Japan
来源：
INTERNAL MEDICINE | 2023年 / 62卷 / 10期
关键词：
carcinoid syndrome; large cell neuroendocrine carcinoma of the lung; refractory diarrhea; EPIDEMIOLOGY; NEOPLASMS; TUMORS;
D O I：
10.2169/internalmedicine.0099-22
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 76-year-old woman was admitted to our hospital for refractory diarrhea with a poor antidiarrheal effect. Chest and abdominal computed tomography revealed a 24x22-mm mass in the left upper lobe of lung and multiple masses in the liver. Urine 5-Hydroxy indol acetic acid was markedly elevated. A liver biopsy revealed large-cell neuroendocrine carcinoma with serotonin production, suggestive of a lung origin, and a lung biopsy revealed combined large-cell neuroendocrine carcinoma and squamous cell carcinoma. Therefore, we made a definitive diagnosis of carcinoid syndrome caused by large-cell neuroendocrine carcinoma of the lung. Although chemotherapy was performed after diagnosis, the patient died 50 days postadmission.
引用
收藏
页码：1557 / 1563
页数：7
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