Automated Insulin Delivery Systems as a Treatment for Type 2 Diabetes Mellitus: A Review

被引:17
作者
Karol, Alexander B. [1 ]
O'Malley, Grenye [1 ]
Fallurin, Reshmitha [1 ]
Levy, Carol J. [1 ]
机构
[1] Icahn Sch Med Mt Sinai, Div Endocrinol Diabet & Metab, 1 Gustave Levy Pl,Box 1055, New York, NY 10029 USA
关键词
diabetes mellitus; insulin; pharmacology; biosensing techniques; methods; insulin infusion systems; pancreas; artificial; automated; MULTIPLE DAILY INJECTIONS; SENSOR-AUGMENTED PUMP; CLOSED-LOOP SYSTEMS; GLYCEMIC OUTCOMES; ARTIFICIAL PANCREAS; PARALLEL-GROUP; THERAPY; INFUSION; ADOLESCENTS; CHILDREN;
D O I
10.1016/j.eprac.2022.10.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Approximately 6.3% of the worldwide population has type 2 diabetes mellitus (T2DM), and the number of people requiring insulin is increasing. Automated insulin delivery (AID) systems integrate continuous subcutaneous insulin infusion and continuous glucose monitoring with a predictive control algorithm to provide more physiologic glycemic control. Personalized glycemic targets are recommended in T2DM owing to the heterogeneity of the disease. Based on the success of hybrid closed-loop systems in improving glycemic control and safety in type 1 diabetes mellitus, there has been further interest in the use of these systems in people with T2DM. Methods: We performed a review of AID systems with a focus on the T2DM population. Results: In 5 randomized controlled trials, AID systems improve time in range and reduce glycemic variability, without increasing insulin requirements or the risk of hypoglycemia. Conclusion: AID systems in T2DM are safe and effective in hospitalized and closely monitored settings. Home studies of longer duration are required to assess for long-term benefit and identify target pop-ulations of benefit.(c) 2022 AACE. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:214 / 220
页数:7
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