A salep biopolymer-based superporous hydrogel for ranitidine delivery: synthesis and characterization

Hydrogels are an effective and potent drug delivery material since they entrap and protect drugs and release them when environmental conditions change. Due to recent advances in this field, alternative biocompatible hydrogels have been developed, emphasizing their characteristics, advantages, limitations, and the use of alternative resources. Polysaccharides can be used to make biodegradable, biocompatible, and cheap hydrogels. In this study, we synthesized a superporous biological macromolecule hydrogel using N, N-dimethyl aminoethyl methacrylate grafted onto salep polysaccharide. We also tested different pHs, ionic strengths, and solvents on swelling behavior for optimum superabsorbent hydrogels. The swelling kinetics and absorbency of the superporous hydrogel were studied under load. FT-IR, thermogravimetric analysis, TEM, SEM, and BET were used to analyze the hydrogel. A mechanism was also proposed for the formation of prepared hydrogels. Finally, the superporous biological macromolecule hydrogel was successfully used as a drug delivery system, and its release behavior was investigated.