Tailoring gas-releasing nanoplatforms for wound treatment: An emerging approach

被引：29

作者：

Wang, Zixin ^{[1
]}

Rong, Fan ^{[1
]}

Li, Zhao ^{[1
]}

Li, Wei ^{[1
]}

Kaur, Kuljeet ^{[2
,3
]}

Wang, Yin ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Engn Res Ctr Cell & Therapeut Antibody, Sch Pharm, Shanghai 200240, Peoples R China

[2] Ecole Polytech Fed Lausanne EPFL, Inst Mat, Batiment MXD,Stn 12, CH-1015 Lausanne, Switzerland

[3] Inst Sci & Ingn Chim, Lab Polymeres, Batiment MXD,Stn 12, CH-1015 Lausanne, Switzerland

来源：

CHEMICAL ENGINEERING JOURNAL | 2023年 / 452卷

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

Drug delivery; Gas signaling molecules; Gas therapy; Nanoplatform; Wound repair; CYSTATHIONINE-BETA-SYNTHASE; HYDROGEN-SULFIDE; NITRIC-OXIDE; CARBON-MONOXIDE; PHOTOTHERMAL THERAPY; PRUSSIAN BLUE; CHEMISTRY; GRAPHENE; DELIVERY; H2S;

D O I：

10.1016/j.cej.2022.139297

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Wound treatment especially of coping with chronic wounds is a global health issue that challenges medical care and financial strength of every nation. In recent years, gas therapy emerges as a facile yet promising modality for wound healing given that gas signaling molecules (GSMs) participate in various physiological processes such as angiogenesis. In this review, we survey the recent advancements in the tailoring design and fabrication of GSM -releasing nanoplatforms for wound repair according to the specific wound microenvironment. We carefully analyze the different synthetic strategies for the preparation of nanoplatforms in terms of the different gas sources or donor types. Both single gas therapy (GT) and GT-based combined therapies are examined in this review thoroughly. Besides, given the synergetic effects of different GSMs in vivo, nanoplatforms capable of unleashing multiple gas molecules from a single vector are also included in this review. At the end, future outlooks and upcoming challenges of this promising treatment for wound closure are discussed.

引用

页数：16

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