Multimodal Brain MRI of Deep Gray Matter Changes Associated With Inflammatory Bowel Disease

被引:21
作者
Goodyear, Bradley G. [3 ,4 ,5 ,6 ,9 ]
Heidari, Faranak [4 ,6 ]
Ingram, Richard J. M. [1 ,8 ]
Cortese, Filomeno [6 ]
Sharifi, Nastaran [8 ]
Kaplan, Gilaad G. [1 ,8 ]
Ma, Christopher [1 ,8 ]
Panaccione, Remo [1 ,8 ]
Sharkey, Keith A. [2 ,7 ,9 ]
Swain, Mark G. [1 ,7 ,8 ]
机构
[1] Univ Calgary, Dept Med, Calgary, AB, Canada
[2] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB, Canada
[3] Univ Calgary, Dept Psychiat, Calgary, AB, Canada
[4] Univ Calgary, Dept Radiol, Calgary, AB, Canada
[5] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada
[6] Univ Calgary, Seaman Family MR Res Ctr, Calgary, AB, Canada
[7] Univ Calgary, Snyder Inst Chron Dis, Calgary, AB, Canada
[8] Univ Calgary, Div Gastroenterol & Hepatol, Calgary, AB, Canada
[9] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada
基金
加拿大健康研究院;
关键词
IBD; brain; MRI; amygdala; basal ganglia; LOW-FREQUENCY FLUCTUATIONS; ANXIETY; DEPRESSION; AMPLITUDE; AMYGDALA; VOLUME;
D O I
10.1093/ibd/izac089
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background Behavioral symptoms, including mood disorders, substantially impact the quality of life of patients with inflammatory bowel disease (IBD), even when clinical remission is achieved. Here, we used multimodal magnetic resonance imaging (MRI) to determine if IBD is associated with changes in the structure and function of deep gray matter brain regions that regulate and integrate emotional, cognitive, and stress responses. Methods Thirty-five patients with ulcerative colitis (UC) or Crohn's disease (CD) and 32 healthy controls underwent 3 Tesla MRIs to assess volume, neural activity, functional connection strength (connectivity), inflammation, and neurodegeneration of key deep gray matter brain regions (thalamus, caudate, pallidum, putamen, amygdala, hippocampus, and hypothalamus) involved in emotional, cognitive and stress processing. Associations with sex, presence of pain, disease activity, and C-reactive protein (CRP) concentration were examined. Results Significantly increased activity and functional connectivity were observed in cognitive and emotional processing brain regions, including parts of the limbic system, basal ganglia, and hypothalamus of IBD patients compared with healthy controls. Inflammatory bowel disease patients exhibited significantly increased volumes of the amygdala and hypothalamus, as well as evidence of neurodegeneration in the putamen and pallidum. Hippocampal neural activity was increased in IBD patients with active disease. The volume of the thalamus was positively correlated with CRP concentration and was increased in females experiencing pain. Conclusions Patients with IBD exhibit functional and structural changes in the limbic and striatal systems. These changes may be targets for assessing or predicting the response to therapeutic interventions aimed at improving comorbid emotional and cognitive symptoms. Lay Summary Magnetic resonance imaging revealed structural and functional changes within the brains of inflammatory bowel disease patients, in regions known to be involved in processing brain signals associated with behavioral symptoms, anxiety, pain, stress, and cognitive deficits.
引用
收藏
页码:405 / 416
页数:12
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