Neoadjuvant ipilimumab plus nivolumab therapy as a potential organ preservation strategy in mucosal melanoma: case report

被引：0

作者：

Ong, Claire ^{[1
]}

Samlowski, Wolfram ^{[1
,2
,3
]}

机构：

[1] Univ Nevada Las Vegas UNLV, Kirk Kerkorian Sch Med, Las Vegas, NV 89154 USA

[2] Comprehens Canc Ctr Nevada, Las Vegas, NV 89169 USA

[3] Univ Nevada, Sch Med, Dept Internal Med, Reno, NV 89557 USA

来源：

FRONTIERS IN ONCOLOGY | 2024年 / 14卷

基金：

美国国家卫生研究院;

关键词：

neoadjuvant therapy; checkpoint inhibitors; sinonasal melanoma; rectal melanoma; organ preservation; PHASE-II; KIT; IMMUNOTHERAPY; CANCER; NILOTINIB; ONCOLOGY; DISEASE; NECK; HEAD;

D O I：

10.3389/fonc.2024.1301424

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mucosal melanoma represents an uncommon melanoma subtype. Wide excision has long represented the standard therapeutic approach. Unfortunately, there is a high relapse rate and mortality. Neoadjuvant therapy with ipilimumab plus nivolumab has shown significant activity in cutaneous melanoma. We present two cases of mucosal melanoma, each with potential regional dissemination, who were treated with neoadjuvant immunotherapy with minimal toxicity. Both patients were closely monitored and achieved radiologic and pathologic complete responses. These patients were able to avoid radical surgery and related functional consequences. Both patients remain recurrence-free with protracted follow-up. The potential usefulness of neoadjuvant immunotherapy as an organ preservation strategy in mucosal melanoma deserves further evaluation in prospective clinical trials.

引用

页数：6

共 46 条

[21] Organ Function Preservation in Locally Advanced Low Rectal Cancer Through Total Neoadjuvant Therapy: A Case Report and Literature Review [J].

Liu, Fengyuan ;

Yu, Li ;

Zhao, Yuanyuan ;

Li, Guoliang ;

He, Xinjia .

CANCER MANAGEMENT AND RESEARCH, 2025, 17 :121-129

[22] Pneumocystis Jiroveci Mimicking COVID-19 Pneumonia in a Patient who is Receiving Ipilimumab and Nivolumab Combination Therapy: A Case Report [J].

Moujaess, Elissar ;

El Haddad, Elias ;

Kaftan, Joseph .

EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY, 2020, 4 (03) :246-250

[23] Real-world Outcomes of Ipilimumab Plus Nivolumab Combination Therapy in a Nation-wide Cohort of Advanced Melanoma Patients in the Netherlands [J].

van Zeijl, Michiel C. T. ;

van Breeschoten, Jesper ;

de Wreede, Liesbeth C. ;

Wouters, Michel W. J. M. ;

Hilarius, Doranne L. ;

Blank, Christian U. ;

Aarts, Maureen J. B. ;

van den Berkmortel, Franchette W. P. J. ;

de Groot, Jan Willem B. ;

Hospers, Geke A. P. ;

Kapiteijn, Ellen ;

Piersma, Djura ;

van Rijn, Rozemarijn S. ;

Boer, Marion Stevense-den A. ;

van der Veldt, Astrid A. M. ;

Vreugdenhil, Gerard ;

Boers-Sonderen, Marye J. ;

Suijkerbuijk, Karijn P. M. ;

Haanen, John B. A. G. ;

van den Eertwegh, Alfons J. M. .

JOURNAL OF IMMUNOTHERAPY, 2023, 46 (05) :197-204

[24] Renal Allograft Failure After Ipilimumab Therapy for Metastatic Melanoma: A Case Report and Review of the Literature [J].

Jose, A. ;

Yiannoullou, P. ;

Bhutani, S. ;

Denley, H. ;

Morton, M. ;

Picton, M. ;

Summers, A. ;

van Dehen, D. ;

Augustine, T. .

TRANSPLANTATION PROCEEDINGS, 2016, 48 (09) :3137-3141

[25] Potential Immune-Related Adverse Events Associated With Monotherapy and Combination Therapy of Ipilimumab, Nivolumab, and Pembrolizumab for Advanced Melanoma: A Systematic Review and Meta-Analysis [J].

Almutairi, Abdulaali R. ;

McBride, Ali ;

Slack, Marion ;

Erstad, Brian L. ;

Abraham, Ivo .

FRONTIERS IN ONCOLOGY, 2020, 10

[26] Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial [J].

Reijers, Irene L. M. ;

Menzies, Alexander M. ;

van Akkooi, Alexander C. J. ;

Versluis, Judith M. ;

van den Heuvel, Noelle M. J. ;

Saw, Robyn P. M. ;

Pennington, Thomas E. ;

Kapiteijn, Ellen ;

van der Veldt, Astrid A. M. ;

Suijkerbuijk, Karijn P. M. ;

Hospers, Geke A. P. ;

Rozeman, Elisa A. ;

Klop, Willem M. C. ;

van Houdt, Winan J. ;

Sikorska, Karolina ;

van der Hage, Jos A. ;

Grunhagen, Dirk J. ;

Wouters, Michel W. ;

Witkamp, Arjen J. ;

Zuur, Charlotte L. ;

Lijnsvelt, Judith M. ;

Torres Acosta, Alejandro ;

Grijpink-Ongering, Lindsay G. ;

Gonzalez, Maria ;

Jozwiak, Katarzyna ;

Bierman, Carolien ;

Shannon, Kerwin F. ;

Ch'ng, Sydney ;

Colebatch, Andrew J. ;

Spillane, Andrew J. ;

Haanen, John B. A. G. ;

Rawson, Robert V. ;

van de Wiel, Bart A. ;

van de Poll-franse, Lonneke V. ;

Scolyer, Richard A. ;

Boekhout, Annelies H. ;

Long, Georgina V. ;

Blank, Christian U. .

NATURE MEDICINE, 2022, 28 (06) :1178-+

[27] Immune Checkpoint Inhibitor Induced Pericarditis and Encephalitis in a Patient Treated With Ipilimumab and Nivolumab for Metastatic Melanoma: A Case Report and Review of the Literature [J].

Braden, Jorja ;

Lee, Jenny H. .

FRONTIERS IN ONCOLOGY, 2021, 11

[28] Abscopal effect observed in visceral and osseous metastases after liver SBRT in combination with nivolumab and relatlimab for sinonasal mucosal melanoma-a case report [J].

Cerbon, Danielle ;

Moya-Brown, Karen ;

Mihaylov, Ivaylo B. B. ;

Spieler, Benjamin .

FRONTIERS IN ONCOLOGY, 2023, 13

[29] Local intralesional talimogene laherparepvec therapy with complete local response in oral palatine mucosal melanoma: a case report [J].

Chitnis, Saurabh D. ;

Seim, Nolan B. ;

Kendra, Kari .

JOURNAL OF MEDICAL CASE REPORTS, 2024, 18 (01)

[30] Nivolumab Treatment in a Mucosal Melanoma Patient with Pre-Existing Systemic Lupus Erythematosus: A Case Report with Literature Review [J].

Popovic, Aleksandar ;

Petkovic, Ivan ;

Rancic, Andrija ;

Dimitrijevic, Aleksandra ;

Brzacki, Vesna ;

Stankov, Stefan ;

Jovic, Andrija ;

Stojanovic, Sonja .

ACTA FACULTATIS MEDICAE NAISSENSIS, 2023, 40 (04) :505-511

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