Synthetic Identification of New Compounds with Anti-fungal Properties of "1-[3-(2-Hydroxyphenyl)-3-Oxop ropanoyl]- 5,5-Diphenylimidazolidine-2,4-Dione and its Derivatives"

Background: 5, 5-diphenylimidazolidine is a heterocyclic hydrocarbon having unique structural characteristics in their molecular structure. In this research; we synthesis various derivatives of -[3-(2-hydroxyphenyl)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione anti-fungal activity. The agar well diffusion method was used to conduct the pharmacological screening for antifungal activity. Materials and Methods: All 5, 5-diphenylimidazolidine derivatives were synthesized by conventional method. Benzoin; Benzil; Urea; Glacial Acetic 4-hydroxyl benzoic acid; Con. HNO3; Formic Acid; 2-Nitro Aniline are used for the synthesis. structure confirmations were done by FTIR, NMR spectroscopy and MS. Results: In this research; we concluded that; many derivatives give potent anti-fungal activity against fungi. The compound 1-[3-(oxo (phenyl amino)acetic acid)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione 1-[3-(N-phenylformamide)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (BG); 1-[3-(N- Phenyl-2-nitroaniline)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (BE); shown antifungal activity against Candida albicans. BJ was shown to be the most effective chemical when compared to Griseofulvin and other common medications because it demonstrated greater antifungal action against Aspergillus niger. Conclusion: The anti-fungal activity of title compounds and their derivatives was studied. Studies on the link between structure activity revealed that compounds containing 5, 5-dimethylimidazolidinone derivatives with electron-withdrawing group have higher activity than those containing an electron-donating group. 1-[3-(N-Phenyl-2-nitroaniline)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (BE); 1-[3-(oxo(phenyl-amino) acetic acid)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (BK) shown better antifungal activity against Candida albicans.