A Pump-free Optofluidic Biosensing Platform based on Whispering Gallery Mode Microspheres

被引：0
作者：
Guan, Bin [1 ,2 ]
Kok, Tuck-Weng [3 ,4 ]
Riesen, Nicolas [1 ,2 ]
Lancaster, David G. [1 ,2 ]
Suu, Koukou [5 ]
Priest, Craig [1 ,2 ]
机构：
[1] Univ South Australia, Future Ind Inst, STEM, Mawson Lakes, SA 5095, Australia
[2] Univ South Australia, ARC Res Hub Integrated Devices End User Anal Low, Mawson Lakes, SA 5095, Australia
[3] Univ Adelaide, Adelaide Med Sch, Adelaide, SA 5005, Australia
[4] Univ Adelaide, Sch Biol Sci, Adelaide, SA 5005, Australia
[5] ULVAC Inc, Chigasaki, Kanagawa 2538543, Japan
来源：
2023 IEEE SENSORS | 2023年
基金：
澳大利亚研究理事会;
关键词：
optofluidics; biosensing; micropillar array; whispering gallery mode; microsphere; influenza virus; VIRUSES;
D O I：
10.1109/SENSORS56945.2023.10325052
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Optofluidic biosensors offer significant advantages for lab-on-a-chip chemical and biological analysis by combining microfluidics for small-volume liquid manipulation with the high sensitivity and adaptability of optical sensing techniques. In this study, we present an optofluidic biosensing platform utilising a micropillar array coupled with active whispering gallery mode (WGM) microsphere resonators for the rapid detection of influenza viruses. The WGM microspheres are coated with polyclonal antibodies capable of targeting both intact virus and fragments of viral proteins. The micropillar array facilitates continuous sampling and measurement through evaporation-driven fluid transport.
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页数：4
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