NIR-activated upconversion nanoparticles/hydrogen-bonded organic framework nanocomposites for NIR-II imaging-guided cancer therapy

被引：15

作者：

Liang, Yuan ^{[1
,2
,4
]}

An, Ran ^{[1
]}

Du, Pengye ^{[1
]}

Lei, Pengpeng ^{[1
]}

Zhang, Hongjie ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, State Key Lab Rare Earth Resource Utilizat, Changchun Inst Appl Chem, Changchun 130022, Jilin, Peoples R China

[2] Univ Sci & Technol China, Sch Rare Earths, Hefei 230026, Anhui, Peoples R China

[3] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[4] Chinese Acad Sci, Ganjiang Innovat Acad, Ganzhou 341000, Jiangxi, Peoples R China

来源：

NANO TODAY | 2023年 / 48卷

基金：

中国国家自然科学基金;

关键词：

Rare earth; Upconversion; Hydrogen -bonded organic frameworks; NIR-II imaging; Cancer therapy; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; TRACKING; DESIGN;

D O I：

10.1016/j.nantod.2022.101751

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Developing hydrogen-bonded organic frameworks (HOFs) materials and exploring their applications in cancer therapy show broad prospects. However, most HOFs are limited by the penetration depth of UV-Vis light in biological tissues required for their activation. Herein, NIR-activated upconversion nanoparticles/ HOFs (abbreviated as UHOFs) nanocomposites composed of NaYF4:Yb3+/Er3+@NaYF4:Nd3+@NaYF4 (abbre-viated as CSS) and PFC-55 HOFs are synthesized through a ligand-graft stepwise method to address the challenge. CSS can not only emit visible light but also NIR-II fluorescence under 808 nm laser excitation. The visible light can effectively excite PFC-55 HOFs to generate singlet oxygen and photothermal effect. Moreover, the NIR-II of Nd3+ is used for fluorescence imaging. After modifying CSS@PFC-55 (CSS@P) with polyacrylic acid (PAA), the resulting CSS@P-PAA exhibit good biocompatibility and efficient cancer ablation ability. To our knowledge, as the first demonstration, NIR-activated UHOFs for NIR-II imaging-guided photodynamic/photothermal combination cancer therapy, which open new avenues for exploring HOFs materials for non-invasive deep cancer therapy. (c) 2023 Elsevier Ltd. All rights reserved.

引用

页数：11

共 46 条

[1] Five-dimensional tracking of single nanoparticles in living cells [J].

Ai, Xiangzhao ;

Xing, Bengang .

LIGHT-SCIENCE & APPLICATIONS, 2018, 7

[2] In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics [J].

Ai, Xiangzhao ;

Ho, Chris Jun Hui ;

Aw, Junxin ;

Attia, Amalina Binte Ebrahim ;

Mu, Jing ;

Wang, Yu ;

Wang, Xiaoyong ;

Wang, Yong ;

Liu, Xiaogang ;

Chen, Huabing ;

Gao, Mingyuan ;

Chen, Xiaoyuan ;

Yeow, Edwin K. L. ;

Liu, Gang ;

Olivo, Malini ;

Xing, Bengang .

NATURE COMMUNICATIONS, 2016, 7

[3] Near-infrared optical and X-ray computed tomography dual-modal imaging probe based on novel lanthanide-doped K0.3Bi0.7F2.4 upconversion nanoparticles [J].

An, Ran ;

Lei, Pengpeng ;

Zhang, Peng ;

Xu, Xia ;

Feng, Jing ;

Zhang, Hongjie .

NANOSCALE, 2018, 10 (03) :1394-1402

[4] Coencapsulation of Arsenic- and Platinum-based Drugs for Targeted Cancer Treatment [J].

Chen, Haimei ;

Pazicni, Samuel ;

Krett, Nancy L. ;

Ahn, Richard W. ;

Penner-Hahn, James E. ;

Rosen, Steven T. ;

O'Halloran, Thomas V. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (49) :9295-9299

[5] Imparting multi-functionality to covalent organic framework nanoparticles by the dual-ligand assistant encapsulation strategy [J].

Chen, Liang ;

Wang, Wenxing ;

Tian, Jia ;

Bu, Fanxing ;

Zhao, Tiancong ;

Liu, Minchao ;

Lin, Runfeng ;

Zhang, Fan ;

Lee, Myongsoo ;

Zhao, Dongyuan ;

Li, Xiaomin .

NATURE COMMUNICATIONS, 2021, 12 (01)

[6] Recent Progress in Near Infrared Light Triggered Photodynamic Therapy [J].

Deng, Kerong ;

Li, Chunxia ;

Huang, Shanshan ;

Xing, Bengang ;

Jin, Dayong ;

Zeng, Qingguang ;

Hou, Zhiyao ;

Lin, Jun .

SMALL, 2017, 13 (44)

[7] Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy [J].

Dong, Hao ;

Du, Shuo-Ren ;

Zheng, Xiao-Yu ;

Lyu, Guang-Ming ;

Sun, Ling-Dong ;

Li, Lin-Dong ;

Zhang, Pei-Zhi ;

Zhang, Chao ;

Yan, Chun-Hua .

CHEMICAL REVIEWS, 2015, 115 (19) :10725-10815

[8] Perfecting and extending the near-infrared imaging window [J].

Feng, Zhe ;

Tang, Tao ;

Wu, Tianxiang ;

Yu, Xiaoming ;

Zhang, Yuhuang ;

Wang, Meng ;

Zheng, Junyan ;

Ying, Yanyun ;

Chen, Siyi ;

Zhou, Jing ;

Fan, Xiaoxiao ;

Li, Shengliang ;

Zhang, Mingxi ;

Qian, Jun .

LIGHT-SCIENCE & APPLICATIONS, 2021, 10 (01)

[9] Tumor targeting via EPR: Strategies to enhance patient responses [J].

Golombek, Susanne K. ;

May, Jan-Niklas ;

Theek, Benjamin ;

Appold, Lia ;

Drude, Natascha ;

Kiessling, Fabian ;

Lammers, Twan .

ADVANCED DRUG DELIVERY REVIEWS, 2018, 130 :17-38

[10]

Ha HK, 2015, ASIAN AUSTRAL J ANIM, V28, P420

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