A comprehensive review on triazole based conjugates as acetylcholinesterase inhibitors: Design strategies, synthesis, biological activity, structure activity relationships, molecular docking studies

Significant advancements have been made in development of Acetylcholinesterase inhibitors as Anti-Alzheimer drugs. Triazoles, a 5-membered heterocyclic nucleus containing three nitrogens, serves as linker in many bioactive compounds. Both 1,2,3-and 1,2,4-triazole based derivatives have proven to act as potent Acetylcholinesterase inhibitors. Further, many literature reports have demonstrated improvement in potency, pharmacokinetic and pharmacodynamic profile and reduction of toxicity of triazole based molecules as anti-AChE agents. This review incorporates the comprehensive literature reports on tria-zole based Acetylcholinesterase inhibitors from 2019 onwards. These findings may facilitate scientists to rationally design more potent anti-acetylcholinesterase drug molecules for treatment of Alzheimers. (c) 2023 Elsevier B.V. All rights reserved.