Engineering yeast for industrial-level production of the antimalarial drug artemisinin

被引：2
|
作者：
Smith, Ayoola B. [1 ]
Chekan, Jonathan R. [2 ]
机构：
[1] Univ North Carolina Greensboro, Dept Nanosci, Greensboro, NC USA
[2] Univ North Carolina Greensboro, Dept Chem & Biochem, Greensboro, NC 27412 USA
来源：
TRENDS IN BIOTECHNOLOGY | 2023年 / 41卷 / 03期
关键词：
SYNTHETIC BIOLOGY; ACID;
D O I：
10.1016/j.tibtech.2022.12.007
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Artemisinin-based combination therapies are the gold standard treatment for uncomplicated malaria. A seminal study by Paddon et al. detailed an efficient approach for producing artemisinic acid from engineered yeast and its conversion to artemisinin, and demonstrated how to use metabolic engineering and synthetic biology for the production of bioactive compounds.
引用
收藏
页码：267 / 269
页数：3
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