Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research

被引:8
|
作者
Gupta, Santosh [1 ]
Lytvynchuk, Lyubomyr [2 ,3 ]
Ardan, Taras [4 ]
Studenovska, Hana [5 ]
Faura, Georgina [6 ]
Eide, Lars [6 ]
Znaor, Ljubo [7 ]
Erceg, Slaven [8 ,9 ]
Stieger, Knut [2 ]
Motlik, Jan [4 ]
Bharti, Kapil [10 ]
Petrovski, Goran [1 ,7 ,11 ]
机构
[1] Univ Oslo, Inst Clin Med, Ctr Eye Res & Innovat Diagnost, Fac Med,Dept Ophthalmol, N-0450 Oslo, Norway
[2] Justus Liebig Univ Giessen, Univ Hosp Giessen & Marburg GmbH, Dept Ophthalmol, D-35392 Giessen, Germany
[3] Karl Landsteiner Inst Retinal Res & Imaging, A-1030 Vienna, Austria
[4] Acad Sci Czech Republ, Inst Anim Physiol & Genet, Libechov 27721, Czech Republic
[5] Acad Sci Czech Republ, Inst Macromol Chem, Prague 16206, Czech Republic
[6] Univ Oslo, Inst Clin Med, Dept Med Biochem, N-0372 Oslo, Norway
[7] Univ Split, Univ Hosp Ctr, Dept Ophthalmol, Sch Med, Split 21000, Croatia
[8] Res Ctr Principe Felipe, Stem Cell Therapies Neurodegenerat Dis Lab, Valencia 46012, Spain
[9] Acad Sci Czech Republ, Inst Expt Med, Prague 11720, Czech Republic
[10] NEI, Ocular & Stem Cell Translat Res Sect, NIH, Bethesda, MD 20892 USA
[11] Oslo Univ Hosp, Dept Ophthalmol, N-0450 Oslo, Norway
关键词
retinal pigment epithelium (RPE); differentiation; stem cells; cell therapy; age-related macular degeneration; MACULAR DEGENERATION; EYE DEVELOPMENT; CHROMATIN-STRUCTURE; VERTEBRATE EYE; OPTIC VESICLE; HOMEOBOX GENE; DIFFERENTIATION; RPE; SPECIFICATION; THERAPY;
D O I
10.3390/biomedicines11020310
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The retinal pigment epithelium (RPE) forms an important cellular monolayer, which contributes to the normal physiology of the eye. Damage to the RPE leads to the development of degenerative diseases, such as age-related macular degeneration (AMD). Apart from acting as a physical barrier between the retina and choroidal blood vessels, the RPE is crucial in maintaining photoreceptor (PR) and visual functions. Current clinical intervention to treat early stages of AMD includes stem cell-derived RPE transplantation, which is still in its early stages of evolution. Therefore, it becomes essential to derive RPEs which are functional and exhibit features as observed in native human RPE cells. The conventional strategy is to use the knowledge obtained from developmental studies using various animal models and stem cell-based exploratory studies to understand RPE biogenies and developmental trajectory. This article emphasises such studies and aims to present a comprehensive understanding of the basic biology, including the genetics and molecular pathways of RPE development. It encompasses basic developmental biology and stem cell-based developmental studies to uncover RPE differentiation. Knowledge of the in utero developmental cues provides an inclusive methodology required for deriving RPEs using stem cells.
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页数:19
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