Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients

被引：10

作者：

Biesbroek, J. Matthijs ^{[1
,2
]}

Coenen, Mirthe ^{[1
]}

DeCarli, Charles ^{[3
]}

Fletcher, Evan M. ^{[3
]}

Maillard, Pauline M. ^{[3
]}

Barkhof, Frederik ^{[4
,5
,6
]}

Barnes, Josephine ^{[7
]}

Benke, Thomas ^{[8
]}

Chen, Christopher P. L. H. ^{[9
,10
]}

Dal-Bianco, Peter ^{[11
]}

Dewenter, Anna ^{[12
]}

Duering, Marco ^{[12
,13
,14
]}

Enzinger, Christian ^{[15
,16
]}

Ewers, Michael ^{[12
]}

Exalto, Lieza G. ^{[1
]}

Franzmeier, Nicolai ^{[12
]}

Hilal, Saima ^{[9
,10
,17
,18
]}

Hofer, Edith ^{[19
,20
]}

Koek, Huiberdina L. ^{[21
]}

Maier, Andrea B. ^{[10
,22
]}

McCreary, Cheryl R. ^{[23
,24
,25
]}

Papma, Janne M. ^{[26
,27
,28
]}

Paterson, Ross W. ^{[7
]}

Pijnenburg, Yolande A. L. ^{[29
,30
]}

Rubinski, Anna ^{[12
]}

Schmidt, Reinhold ^{[19
]}

Schott, Jonathan M. ^{[7
]}

Slattery, Catherine F. ^{[7
]}

Smith, Eric E. ^{[23
,24
,25
]}

Sudre, Carole H. ^{[31
,32
]}

Steketee, Rebecca M. E. ^{[29
,33
]}

Teunissen, Charlotte E. ^{[34
]}

van den Berg, Esther ^{[26
,27
]}

van der Flier, Wiesje M. ^{[29
,30
,35
]}

Venketasubramanian, Narayanaswamy ^{[10
,36
]}

Venkatraghavan, Vikram ^{[29
,30
]}

Vernooij, Meike W. ^{[29
,33
,37
]}

Wolters, Frank J. ^{[29
,33
,37
]}

Xin, Xu ^{[9
,10
]}

Kuijf, Hugo J. ^{[38
]}

Biessels, Geert Jan ^{[1
]}

机构：

[1] UMC Utrecht Brain Ctr, Dept Neurol & Neurosurg, Heidelberglaan 100,POB 85500, NL-3508 GA Utrecht, Netherlands

[2] Diakonessenhuis Hosp, Dept Neurol, Utrecht, Netherlands

[3] Univ Calif Davis, Dept Neurol, Davis, CA USA

[4] Vrije Univ, Dept Radiol & Nucl Med, Amsterdam UMC, Amsterdam, Netherlands

[5] UCL, Queen Sq Inst Neurol, London, England

[6] UCL, Ctr Med Image Comp, London, England

[7] UCL, UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England

[8] Med Univ Innsbruck, Clin Neurol, Innsbruck, Austria

[9] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore

[10] Natl Univ Hlth Syst, Memory Aging & Cognit Ctr, Singapore, Singapore

[11] Med Univ Vienna, Dept Neurol, Vienna, Austria

[12] Ludwig Maximilians Univ Munchen, Inst Stroke & Dementia Res ISD, LMU Univ Hosp, Munich, Germany

[13] Univ Basel, Med Image Anal Ctr MIAC, Basel, Switzerland

[14] Univ Basel, Dept Biomed Engn, Basel, Switzerland

[15] Med Univ Graz, Dept Neurol, Div Gen Neurol, Graz, Austria

[16] Med Univ Graz, Dept Radiol, Div Neuroradiol Intervent & Vasc Radiol, Graz, Austria

[17] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

[18] Natl Univ Hlth Syst, Singapore, Singapore

[19] Med Univ Graz, Dept Neurol, Div Neurogeriatr, Graz, Austria

[20] Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria

[21] Univ Med Ctr Utrecht, Dept Geriatr Med, Utrecht, Netherlands

[22] Natl Univ Singapore, Dept Med, Singapore, Singapore

[23] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada

[24] Univ Calgary, Dept Radiol, Calgary, AB, Canada

[25] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada

[26] Erasmus MC, Alzheimer Ctr, Univ Med Ctr, Rotterdam, Netherlands

[27] Erasmus MC, Dept Neurol, Univ Med Ctr, Rotterdam, Netherlands

[28] Erasmus MC, Dept Internal Med, Univ Med Ctr, Rotterdam, Netherlands

[29] Vrije Univ Amsterdam, Dept Neurol, Amsterdam Neurosci,Alzheimer Ctr Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

[30] Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands

[31] UCL, MRC Unit Lifelong Hlth & Ageing, London, England

[32] UCL, Ctr Med Image Comp, London, England

[33] Erasmus MC, Univ Med Ctr, Dept Radiol & Nucl Med, Rotterdam, Netherlands

[34] Vrije Univ Amsterdam, Neurochem Lab, Dept Clin Chem, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

[35] Vrije Univ Amsterdam, Epidemiol & Data Sci, Amsterdam UMClocat VUmc, Amsterdam, Netherlands

[36] Raffles Hosp, Raffles Neurosci Ctr, Singapore, Singapore

[37] Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands

[38] Univ Med Ctr Utrecht, Image Sci Inst, Utrecht, Netherlands

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 04期

基金：

美国国家卫生研究院; 奥地利科学基金会;

关键词：

amyloid pathology; arteriolosclerosis; dementia; lesion pattern; white matter hyperintensities; SMALL VESSEL DISEASE; CEREBROSPINAL-FLUID BIOMARKERS; ALZHEIMERS-DISEASE; ANGIOPATHY; DEMENTIA; LESIONS; MRI; DIAGNOSIS; PATHWAYS; BETA;

D O I：

10.1002/alz.13765

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: White matter hyperintensities (WMH) are associated with key dementia etiologies, in particular arteriolosclerosis and amyloid pathology. We aimed to identify WMH locations associated with vascular risk or cerebral amyloid-beta 1- 42 (A beta 42)-positive status. METHODS: Individual patient data (n= 3,132; mean age 71.5 +/- 9 years; 49.3% female) from 11 memory clinic cohorts were harmonized. WMH volumes in 28 regions were related to a vascular risk compound score (VRCS) and A beta 42 status (based on cerebrospinal fluid oramyloid positron emission tomography), correcting for age, sex, study site, and totalWMHvolume. RESULTS: VRCS was associated with WMH in anterior/superior corona radiata (B = 0.034/0.038, p < 0.001), external capsule (B = 0.052, p < 0.001), and middle cerebellar peduncle (B = 0.067, p < 0.001), and A beta 42-positive status withWMH in posterior thalamic radiation (B = 0.097, p < 0.001) and splenium (B = 0.103, p < 0.001). DISCUSSION: Vascular risk factors and A beta 42 pathology have distinct signature WMH patterns. This regional vulnerabilitymay incite future studies into how arteriolosclerosis and A beta 42 pathology affect the brain's white matter.

引用

页码：2980 / 2989

页数：10

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