Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

被引：2

作者：

Duarte-Rodriguez, David Aldebaran ^{[1
]}

Flores-Lujano, Janet ^{[2
]}

McNally, Richard J. Q. ^{[3
]}

Perez-Saldivar, Maria Luisa ^{[2
]}

Jimenez-Hernandez, Elva ^{[4
]}

Martin-Trejo, Jorge Alfonso ^{[5
]}

Espinoza-Hernandez, Laura Eugenia ^{[5
]}

Medina-Sanson, Aurora ^{[6
]}

Paredes-Aguilera, Rogelio ^{[7
]}

Merino-Pasaye, Laura Elizabeth ^{[8
]}

Velazquez-Avina, Martha Margarita ^{[8
,9
]}

Torres-Nava, Jose Refugio ^{[4
]}

Espinosa-Elizondo, Rosa Martha ^{[10
]}

Amador-Sanchez, Raquel ^{[11
]}

Dosta-Herrera, Juan Jose ^{[12
]}

Mondragon-Garcia, Javier Anastacio ^{[13
]}

Gonzalez-Ulibarri, Juana Esther ^{[14
]}

Martinez-Silva, Sofia Irene ^{[15
]}

Espinoza-Anrubio, Gilberto ^{[16
]}

Paz-Bribiesca, Maria Minerva ^{[17
]}

Salcedo-Lozada, Perla ^{[18
]}

Landa-Garcia, Rodolfo Angel ^{[19
]}

Ramirez-Colorado, Rosario ^{[20
]}

Hernandez-Mora, Luis ^{[21
]}

Santamaria-Ascencio, Marlene ^{[22
]}

Lopez-Loyola, Anselmo ^{[23
]}

Godoy-Esquivel, Arturo Hermilo ^{[24
]}

Garcia-Lopez, Luis Ramiro ^{[25
]}

Anguiano-Avalos, Alison Ireri ^{[26
]}

Mora-Rico, Karina ^{[27
]}

Castaneda-Echevarria, Alejandro ^{[28
]}

Rodriguez-Jimenez, Roberto ^{[29
]}

Cibrian-Cruz, Jose Alberto ^{[30
]}

Solis-Labastida, Karina Anastacia ^{[5
]}

Cardenas-Cardos, Rocio ^{[31
]}

Lopez-Santiago, Norma ^{[7
]}

Flores-Villegas, Luz Victoria ^{[8
]}

Penaloza-Gonzalez, Jose Gabriel ^{[9
]}

Gonzalez-Avila, Ana Itamar ^{[11
]}

Sanchez-Ruiz, Martin ^{[18
]}

Rivera-Luna, Roberto ^{[31
]}

Rodriguez-Villalobos, Luis Rodolfo ^{[25
]}

Hernandez-Perez, Francisco ^{[26
]}

Olvera-Duran, Jaime Angel ^{[27
]}

Garcia-Cortes, Luis Rey ^{[32
]}

Mata-Rocha, Minerva ^{[33
]}

Sepulveda-Robles, Omar Alejandro ^{[33
]}

Bekker-Mendez, Vilma Carolina ^{[34
]}

Jimenez-Morales, Silvia ^{[35
]}

Melendez-Zajgla, Jorge ^{[36
]}

机构：

[1] Inst Mexicano Seguro Social IMSS, Div Desarrollo Invest Salud, Ctr Med Nacl CMN Siglo XXI, Coordinac Invest Salud, Mexico City, DF, Mexico

[2] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl CMN Siglo XXI, Unidad Med Alta Especialidad UMAE, Unidad Invest Med Epidemiol Clin,Hosp Pediat, Mexico City, DF, Mexico

[3] Newcastle Univ, Royal Victoria Infirm, Populat Hlth Sci Inst, Newcastle Upon Tyne, Tyne & Wear, England

[4] Hosp Pediat Moctezuma, Serv Oncol, Secretaria Salud Ciudad Mexico SEDESA, Mexico City, DF, Mexico

[5] Inst Mexicano Seguro Social IMSS, Unidad Med Alta Especial Hosp Pediat, Ctr Med Nacl CMN Siglo XXI, Serv Hematol,Hosp Pediat, Mexico City, DF, Mexico

[6] Hosp Infantil Mexico Dr Federico Gomez, Dept Hematooncol, Secretaria Salud SS, Mexico City, DF, Mexico

[7] Inst Nacl Pediat INP, Serv Hematol, Mexico City, DF, Mexico

[8] Inst Seguridad Social Serv Trabajadores Estado IS, Ctr Med Nacl CMN 20 Noviembre, Serv Hematol Pediat, Mexico City, DF, Mexico

[9] Hosp Juarez Mexico, Inst Politec Nacl 5160, Serv Oncopediat, Mexico City, DF, Mexico

[10] Hosp Gen Mexico City, Serv Hematol Pediat, Mexico City, DF, Mexico

[11] Hosp Gen Reg HGR 1 Dr Carlos MacGregor Sanchez Na, Inst Mexicano Seguro Social IMSS, Serv Hematol Pediat, Mexico City, DF, Mexico

[12] Hosp Gen Gaudencio Gonzalez Garza, Inst Mexicano Seguro Social IMSS, Ctr Med Nacl CMN La Raza, Serv Cirugia Pediat, Mexico City, DF, Mexico

[13] Hosp Gen Reg 1 Dr Carlos MacGregor Sanchez Navarr, Inst Mexicano Seguro Social IMSS, Serv Cirugia Pediat, Mexico City, DF, Mexico

[14] Hosp Pediat Iztacalco, Secretaria Salud Ciudad Mexico SEDESA, Mexico City, DF, Mexico

[15] Hosp Pediat Iztapalapa, Secretaria Salud Ciudad Mexico SEDESA, Mexico City, DF, Mexico

[16] Hosp Gen Zona HGZ 8 Dr Gilberto Flores Izquierdo, Serv Pediat, Inst Mexicano Seguro Social IMSS, Mexico City, DF, Mexico

[17] Hosp Juarez Ctr, Serv Pediat, Mexico City, DF, Mexico

[18] Hosp Gen Ecatepec Las Amer, Inst Salud Estado Mexico ISEM, Ecatepec De Morelos, Mexico

[19] Hosp Gen Dr Manuel Gea Gonzalez SS, Mexico City, DF, Mexico

[20] Hosp Pediat La Villa, Secretaria Salud Ciudad Mexico SEDESA, Mexico City, DF, Mexico

[21] Hosp Pediat San Juan Aragon, Secretaria Salud Ciudad Mexico SEDESA, Mexico City, DF, Mexico

[22] Hosp Gen Reg HGR 72 Lic Vicente Santos Guajardo, Inst Mexicano Seguro Social IMSS, Serv Pediat, Tlalnepantla De Baz, Mexico

[23] Hosp Gen Zona HGZ 32, Inst Mexicano Seguro Social IMSS, Serv Cirugia Pediat, Mexico City, DF, Mexico

[24] Hosp Pediat Moctezuma, Serv Cirugia Pediat, Secretaria Salud Ciudad Mex SEDESA, Mexico City, DF, Mexico

[25] Hosp Pediat Tacubaya, Serv Pediat, Secretaria Salud Ciudad Mex SEDESA, Mexico City, DF, Mexico

[26] Hosp Gen Zona HGZ 47, Inst Mexicano Seguro Social IMSS, Urgencias Pediat, Mexico City, Mexico

[27] Hosp Reg 1 Octubre, Revoluc Inst Mexicano Seguro Social IMSS, Inst Seguridad Social Serv Trabajadores Estado IS, Serv Cirugia Pediat,Inst Politecn Nacl 1669, Mexico City, DF, Mexico

[28] Hosp Gen Reg HGR 25, Inst Mexicano Seguro Social IMSS, Serv Pediat, Mexico City, DF, Mexico

[29] Hosp Gen Zona Con Med Familiar HGZMF 29, Serv Pediat, Inst Mexicano Seguro Social IMSS, Mexico City, DF, Mexico

[30] Hosp Gen Zona HGZ 27, Serv Cirug Pediat, Inst Mexicano Seguro Social IMSS, Mexico City, DF, Mexico

[31] Inst Nacl Pediat INP, Serv Oncol, Mexico City, DF, Mexico

[32] Inst Mexicano Seguro Social IMSS, Delegac Reg Estado Mexico Oriente, Naucalpan De Juarez, Mexico

[33] Inst Mexicano Seguro Social IMSS, Lab Biol Mol, Ctr Med Nacl CMN Siglo XXI, Unidad Med Alta Especialidad UMAE,Hosp Pediat, Mexico City, DF, Mexico

[34] Hosp Infectol Dr Daniel Mendez Hernandez, Ctr Med Nacl CMN La Raza, Unidad Invest Med Inmunol Infectol, Mexico City, Mexico

[35] Nucleus A Inst Nacl Med Genom INMEGEN, Lab Innovat & Precis Med, Mexico City, DF, Mexico

[36] Inst Nacl Med Genomica INMEGEN, Lab Genom Func Canc, Mexico City, DF, Mexico

[37] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl CMN Siglo 21, Unidad Invest Med Genet Humana, Unidad Med Alta Especial UMAE,Hosp Pediat, Mexico City, DF, Mexico

[38] Univ Nacl Autonoma Mexico, Inst Ciencias Atmosfera & Cambio Climat, Mexico City, DF, Mexico

[39] Hosp Pediat Dr Silvestre Frenk Freund, Ctr Med Nacl CMN Siglo 21, Inst Mexicano Seguro Social IMSS, Unidad Med Alta Especial UMAE,Div Invest Salud, Mexico City, DF, Mexico

[40] Univ Nacl Autonoma Mexico, Fac Med, Mexico City, DF, Mexico

来源：

FRONTIERS IN ONCOLOGY | 2024年 / 14卷

基金：

美国国家卫生研究院;

关键词：

leukemia; child; spatial clustering; SaTScan software to analyze spatial; electromagnetic fields; environmental exposure; urban population; developing countries; RESIDENTIAL EXPOSURE; MAGNETIC-FIELDS; POWER-LINES; RISK-FACTOR; CHILDREN; TIME; ASSOCIATION; ETIOLOGY; GERMANY; CANCER;

D O I：

10.3389/fonc.2024.1304633

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background A heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the geographical distribution of childhood ALL cases in Greater Mexico City (GMC). Methods A population-based case-control study was conducted. Children <18 years old, newly diagnosed with ALL and residents of GMC were included. Controls were patients without leukemia recruited from second-level public hospitals, frequency-matched by sex, age, and health institution with the cases. The residence address where the patients lived during the last year before diagnosis (cases) or the interview (controls) was used for geolocation. Kulldorff's spatial scan statistic was used to detect spatial clusters (SCs). Relative risks (RR), associated p-value and number of cases included for each cluster were obtained. Results A total of 1054 cases with ALL were analyzed. Of these, 408 (38.7%) were distributed across eight SCs detected. A relative risk of 1.61 (p<0.0001) was observed for the main cluster. Similar results were noted for the remaining seven ones. Additionally, a proximity between SCs, electrical installations and petrochemical facilities was observed. Conclusions The identification of SCs in certain regions of GMC suggest the possible role of environmental factors in the etiology of childhood ALL.

引用

页数：10

共 50 条

[41] Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004 [J].

W A Kamps ;

K M van der Pal-de Bruin ;

A J P Veerman ;

M Fiocco ;

M Bierings ;

R Pieters .

Leukemia, 2010, 24 :309-319

[42] Neurocognitive Outcomes Decades After Treatment for Childhood Acute Lymphoblastic Leukemia: A Report From the St Jude Lifetime Cohort Study [J].

Krull, Kevin R. ;

Brinkman, Tara M. ;

Li, Chenghong ;

Armstrong, Gregory T. ;

Ness, Kirsten K. ;

Srivastava, Deo Kumar ;

Gurney, James G. ;

Kimberg, Cara ;

Krasin, Matthew J. ;

Pui, Ching-Hon ;

Robison, Leslie L. ;

Hudson, Melissa M. .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (35) :4407-+

[43] Comparison of diagnostic and relapse flow cytometry phenotypes in childhood acute lymphoblastic leukemia: Implications for residual disease detection: A report from the children's oncology group [J].

Borowitz, MJ ;

Pullen, DJ ;

Winick, N ;

Martin, PL ;

Bowman, WP ;

Camitta, B .

CYTOMETRY PART B-CLINICAL CYTOMETRY, 2005, 68B (01) :18-24

[44] Long-term Results of the Risk-adapted Treatment for Childhood B-Cell Acute Lymphoblastic Leukemia: Report From the Japan Association of Childhood Leukemia Study ALL-97 Trial [J].

Horibe, Keizo ;

Yumura-Yagi, Keiko ;

Kudoh, Tooru ;

Nishimura, Shinichiro ;

Oda, Megumi ;

Yoshida, Makoto ;

Komada, Yoshihiro ;

Hara, Junichi ;

Tawa, Akio ;

Usami, Ikuya ;

Tanizawa, Akihiko ;

Kato, Koji ;

Kobayashi, Ryoji ;

Matsuo, Keitaro ;

Hori, Hiroki .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2017, 39 (02) :81-89

[45] Long-term results of the children's cancer group studies for childhood acute lymphoblastic leukemia 1983–2002: A Children's Oncology Group Report [J].

P S Gaynon ;

A L Angiolillo ;

W L Carroll ;

J B Nachman ;

M E Trigg ;

H N Sather ;

S P Hunger ;

M Devidas .

Leukemia, 2010, 24 :285-297

[46] Parental Sleep, Distress, and Quality of Life in Childhood Acute Lymphoblastic Leukemia: A Longitudinal Report from Diagnosis up to Three Years Later [J].

Rensen, Niki ;

Steur, Lindsay ;

Grootenhuis, Martha ;

Twisk, Jos ;

van Eijkelenburg, Natasha ;

van der Sluis, Inge ;

Dors, Natasja ;

van den Bos, Cor ;

Tissing, Wim ;

Kaspers, Gertjan ;

van Litsenburg, Raphaele .

CANCERS, 2022, 14 (11)

[47] Diabetes mellitus among adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude lifetime cohort study [J].

Williams, Hannah E. ;

Howell, Carrie R. ;

Chemaitilly, Wassim ;

Wilson, Carmen L. ;

Karol, Seth E. ;

Nolan, Vikki G. ;

Smeltzer, Matthew P. ;

Green, Daniel M. ;

Ehrhardt, Matthew J. ;

Mulrooney, Daniel A. ;

Pui, Ching-Hon ;

Hudson, Melissa M. ;

Robison, Leslie L. ;

Ness, Kirsten K. .

CANCER, 2020, 126 (04) :870-878

[48] Intravenous 6-mercaptopurine decreases salvage after relapse in childhood acute lymphoblastic leukemia: A report from the Children's Cancer Group Study CCG 1922 [J].

Tolar, J ;

Bostrom, BC ;

La, MK ;

Sather, HN .

PEDIATRIC BLOOD & CANCER, 2005, 45 (01) :5-9

[49] Genetic variation in the body mass index of adult survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort [J].

Richard, Melissa A. ;

Brown, Austin L. ;

Belmont, John W. ;

Scheurer, Michael E. ;

Arroyo, Vidal M. ;

Foster, Kayla L. ;

Kern, Kathleen D. ;

Hudson, Melissa M. ;

Leisenring, Wendy M. ;

Okcu, M. Fatih ;

Sapkota, Yadav ;

Yasui, Yutaka ;

Morton, Lindsay M. ;

Chanock, Stephen J. ;

Robison, Leslie L. ;

Armstrong, Gregory T. ;

Bhatia, Smita ;

Oeffinger, Kevin C. ;

Lupo, Philip J. ;

Kamdar, Kala Y. .

CANCER, 2021, 127 (02) :310-318

[50] Long-term results of the children's cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: A Children's Oncology Group Report [J].

Gaynon, P. S. ;

Angiolillo, A. L. ;

Carroll, W. L. ;

Nachman, J. B. ;

Trigg, M. E. ;

Sather, H. N. ;

Hunger, S. P. ;

Devidas, M. .

LEUKEMIA, 2010, 24 (02) :285-297

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