Polarization-artifact reduction and accuracy improvement of Jones-matrix polarization-sensitive optical coherence tomography by multi-focus-averaging based multiple scattering reduction

被引:5
作者
Zhu, Lida [1 ]
Makita, Shuichi [1 ]
Tamaoki, Junya [2 ]
Zhu, Yiqiang [1 ]
Mukherjee, Pradipta [1 ]
Lim, Yiheng [1 ]
Kobayashi, Makoto [2 ]
Yasuno, Yoshiaki [1 ]
机构
[1] Univ Tsukuba, Computat Opt Grp, Tsukuba, Ibaraki, Japan
[2] Univ Tsukuba, Inst Med, Dept Mol & Dev Biol, Tsukuba, Ibaraki, Japan
基金
日本学术振兴会;
关键词
PHASE RETARDATION; ESTIMATOR; OCT; TISSUE; NOISE;
D O I
10.1364/BOE.509763
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Polarization-sensitive optical coherence tomography (PS-OCT) is a promising biomedical imaging tool for the differentiation of various tissue properties. However, the presence of multiple-scattering (MS) signals can degrade the quantitative polarization measurement accuracy. We demonstrate a method to reduce MS signals and increase the measurement accuracy of Jones matrix PS-OCT. This method suppresses MS signals by averaging multiple Jones matrix volumes measured using different focal positions. The MS signals are decorrelated among the volumes by focus position modulation and are thus reduced by averaging. However, the single scattering signals are kept consistent among the focus-modulated volumes by computational refocusing. We validated the proposed method using a scattering phantom and a postmortem medaka fish. The results showed reduced artifacts in birefringence and degree-of-polarization uniformity measurements, particularly in deeper regions in the samples. This method offers a practical solution to mitigate MS-induced artifacts in PS-OCT imaging and improves quantitative polarization measurement accuracy.
引用
收藏
页码:256 / 276
页数:21
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