Structural and functional changes of anterior cingulate cortex subregions in migraine without aura: relationships with pain sensation and pain emotion

被引：9

作者：

Ou, Yangxu ^{[1
]}

Ni, Xixiu ^{[1
]}

Gao, Xiaoyu ^{[1
]}

Yu, Yang ^{[1
]}

Zhang, Yutong ^{[2
]}

Wang, Yanan ^{[3
]}

Liu, Jie ^{[4
]}

Yin, Zihan ^{[1
]}

Rong, Jing ^{[1
]}

Sun, Mingsheng ^{[1
,5
]}

Chen, Jiao ^{[1
,5
]}

Tang, Zili ^{[1
]}

Xiao, Wang ^{[1
]}

Zhao, Ling ^{[1
,5
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, 1166 Liutai Ave, Chengdu 611137, Sichuan, Peoples R China

[2] Third Peoples Hosp Chengdu, Dept Sci Res & Educ & Training Management, Chengdu 610000, Sichuan, Peoples R China

[3] Chongqing Hosp Tradit Chinese Med, Dept Pain Treatment, Chongqing 400021, Peoples R China

[4] Sichuan Prov Peoples Hosp, Dept Neurol, Chengdu 610072, Sichuan, Peoples R China

[5] Sichuan Clin Med Res Ctr Acupuncture & Moxibust, Chengdu 611137, Sichuan, Peoples R China

来源：

CEREBRAL CORTEX | 2024年 / 34卷 / 02期

基金：

中国国家自然科学基金;

关键词：

migraine without aura; anterior cingulate cortex; functional connectivity; gray matter volume; RESTING-STATE; BRAIN; CONNECTIVITY; PERSPECTIVE; PERCEPTION;

D O I：

10.1093/cercor/bhae040

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Migraine without aura is a multidimensional neurological disorder characterized by sensory, emotional, and cognitive symptoms linked to structural and functional abnormalities in the anterior cingulate cortex. Anterior cingulate cortex subregions play differential roles in the clinical symptoms of migraine without aura; however, the specific patterns and mechanisms remain unclear. In this study, voxel-based morphometry and seed-based functional connectivity were used to investigate structural and functional alterations in the anterior cingulate cortex subdivisions in 50 patients with migraine without aura and 50 matched healthy controls. Compared with healthy controls, patients exhibited (1) decreased gray matter volume in the subgenual anterior cingulate cortex, (2) increased functional connectivity between the bilateral subgenual anterior cingulate cortex and right middle frontal gyrus, and between the posterior part of anterior cingulate cortex and right middle frontal gyrus, orbital part, and (3) decreased functional connectivity between the anterior cingulate cortex and left anterior cingulate and paracingulate gyri. Notably, left subgenual anterior cingulate cortex was correlated with the duration of each attack, whereas the right subgenual anterior cingulate cortex was associated with migraine-specific quality-of-life questionnaire (emotion) and self-rating anxiety scale scores. Our findings provide new evidence supporting the hypothesis of abnormal anterior cingulate cortex subcircuitry, revealing structural and functional abnormalities in its subregions and emphasizing the potential involvement of the left subgenual anterior cingulate cortex-related pain sensation subcircuit and right subgenual anterior cingulate cortex -related pain emotion subcircuit in migraine.

引用

页数：11

共 78 条

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