Folliculotropic Mycosis Fungoides Is Associated with Decreased PD1 Staining Compared with Classic Mycosis Fungoides

被引:1
|
作者
Tang, Haiming [1 ]
Rybski, Kristin J. [2 ]
Luan, Yi [3 ]
Smoller, Bruce R. [2 ]
机构
[1] Yale Sch Med, Dept Pathol, New Haven, CT 06510 USA
[2] Univ Rochester, Dept Pathol & Lab Med, Rochester, NY 14642 USA
[3] Yale Sch Med, Dept Pharmacol, New Haven, CT 06510 USA
来源
DERMATOPATHOLOGY | 2023年 / 10卷 / 04期
关键词
PD-1; mycosis fungoides; MF; folliculotropic MF; large cell transformation; EXPRESSION; MARKERS; PD-1;
D O I
10.3390/dermatopathology10040038
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Programmed cell death protein 1 (PD-1) plays a pivotal role in immune system regulation, with its expression levels linked to malignancy prognosis. However, existing reports on PD-1 staining in mycosis fungoides (MF) present conflicting findings, and little attention has been given to PD-1 staining in different MF variants. To address this, we conducted a retrospective study, employing immunohistochemistry to examine PD-1 expression in cases of folliculotropic MF and non-folliculotropic MF. We analyzed 24 cases of folliculotropic MF and 18 cases of non-folliculotropic MF, and recorded both the percentage of PD-1-labeled tumor cells and the intensity score (negative, weak, medium, or strong). Our results revealed significant disparity in PD-1 labeling between patch/plaque MF and folliculotropic MF (p = 0.028). Non-folliculotropic MF exhibited higher PD-1 labeling in tumor cells (58.3%) compared to folliculotropic MF (40.2%). Notably, there was no significant difference in PD-1 staining between folliculotropic MF and non-folliculotropic MF when both were in the early stage/indolent disease category. However, when considering the tumor stage, folliculotropic MF exhibited PD-1 staining in tumor cells at a rate of 21.1%, while non-folliculotropic MF showed PD-1 staining in tumor cells at a rate of 46.6% (p = 0.005). Additionally, among folliculotropic MF cases, 13 out of 24 cases displayed differing PD-1 expression patterns between epidermal and dermal components, with preserved PD-1 staining in the epidermal component and loss of staining in the dermal component. Furthermore, consistent with the prior literature, tumor cells with large cell transformations exhibited significantly lower PD-1 labeling (p = 0.017). Our findings showcase the unique PD-1 staining patterns in MF.
引用
收藏
页码:303 / 309
页数:7
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