Exploration of the pathogenesis of polycystic ovary syndrome based on gut microbiota: A review

被引:5
|
作者
Guo, Hua [1 ]
Luo, Jing [1 ]
Lin, Hanmei [2 ,3 ]
机构
[1] Guangxi Univ Tradit Chinese Med, Grad Sch, Nanning, Peoples R China
[2] Guangxi Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Gynaecol, Nanning, Guangxi Zhuang, Peoples R China
[3] 89-9 Dongge Rd, Nanning 530000, Guangxi Zhuang, Peoples R China
基金
中国国家自然科学基金;
关键词
gut microbiota; hyperandrogenism; insulin resistance; neuroendocrine dysfunction; polycystic ovary syndrome; PROTEIN-COUPLED RECEPTOR; CHAIN FATTY-ACIDS; METAGENOMIC ANALYSIS; INSULIN; OBESITY; WOMEN;
D O I
10.1097/MD.0000000000036075
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Polycystic ovary syndrome (PCOS) is a complex disorde7r influenced by genetic, neuroendocrine, metabolic, environmental, and lifestyle factors. This paper delves into the increasingly recognized role of gut microbiota dysbiosis in the onset and progression of PCOS. Utilizing advances in next-generation sequencing and metabolomics, the research examines the intricate interaction between the gut microbiota and the central nervous system via the gut-brain axis. The paper highlights how disruptions in gut microbiota contribute significantly to PCOS by modulating the release of gut-brain peptides and activating inflammatory pathways. Through such mechanisms, gut microbiota dysbiosis is implicated in hyperandrogenism, insulin resistance, chronic inflammation, and metabolic disorders associated with PCOS. While the relationship between gut microbiota and PCOS has begun to be elucidated, this paper underscores the need for further research to identify specific bacterial strains and their metabolic byproducts as potential therapeutic targets. Therefore, comprehensive studies are urgently needed to understand and fundamentally treat the pathophysiological processes of PCOS, offering valuable insights for future treatment and prevention strategies.
引用
收藏
页数:5
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