Exploration of the pathogenesis of polycystic ovary syndrome based on gut microbiota: A review

被引:5
|
作者
Guo, Hua [1 ]
Luo, Jing [1 ]
Lin, Hanmei [2 ,3 ]
机构
[1] Guangxi Univ Tradit Chinese Med, Grad Sch, Nanning, Peoples R China
[2] Guangxi Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Gynaecol, Nanning, Guangxi Zhuang, Peoples R China
[3] 89-9 Dongge Rd, Nanning 530000, Guangxi Zhuang, Peoples R China
基金
中国国家自然科学基金;
关键词
gut microbiota; hyperandrogenism; insulin resistance; neuroendocrine dysfunction; polycystic ovary syndrome; PROTEIN-COUPLED RECEPTOR; CHAIN FATTY-ACIDS; METAGENOMIC ANALYSIS; INSULIN; OBESITY; WOMEN;
D O I
10.1097/MD.0000000000036075
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Polycystic ovary syndrome (PCOS) is a complex disorde7r influenced by genetic, neuroendocrine, metabolic, environmental, and lifestyle factors. This paper delves into the increasingly recognized role of gut microbiota dysbiosis in the onset and progression of PCOS. Utilizing advances in next-generation sequencing and metabolomics, the research examines the intricate interaction between the gut microbiota and the central nervous system via the gut-brain axis. The paper highlights how disruptions in gut microbiota contribute significantly to PCOS by modulating the release of gut-brain peptides and activating inflammatory pathways. Through such mechanisms, gut microbiota dysbiosis is implicated in hyperandrogenism, insulin resistance, chronic inflammation, and metabolic disorders associated with PCOS. While the relationship between gut microbiota and PCOS has begun to be elucidated, this paper underscores the need for further research to identify specific bacterial strains and their metabolic byproducts as potential therapeutic targets. Therefore, comprehensive studies are urgently needed to understand and fundamentally treat the pathophysiological processes of PCOS, offering valuable insights for future treatment and prevention strategies.
引用
收藏
页数:5
相关论文
共 50 条
  • [1] Exploration of the Relationship Between Gut Microbiota and Polycystic Ovary Syndrome (PCOS): a Review
    Zhao, Xiaoxuan
    Jiang, Yuepeng
    Xi, Hongyan
    Chen, Lu
    Feng, Xiaoling
    GEBURTSHILFE UND FRAUENHEILKUNDE, 2020, 80 (02) : 161 - 171
  • [2] Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review
    Guo, Jingbo
    Shao, Jie
    Yang, Yuan
    Niu, Xiaodan
    Liao, Juan
    Zhao, Qing
    Wang, Donghui
    Li, Shuaitong
    Hu, Junping
    REPRODUCTIVE SCIENCES, 2022, 29 (01) : 69 - 83
  • [3] Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications
    Sun, Yan
    Gao, Shouyang
    Ye, Cong
    Zhao, Weiliang
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2023, 13
  • [4] Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review
    He, Fang-fang
    Li, Yu-mei
    JOURNAL OF OVARIAN RESEARCH, 2020, 13 (01)
  • [5] Role of polyphenols in remodeling the host gut microbiota in polycystic ovary syndrome
    Zhou, Ping
    Feng, Penghui
    Liao, Baoying
    Fu, Lin
    Shan, Hongying
    Cao, Canhui
    Luo, Renxin
    Peng, Tianliu
    Liu, Fenting
    Li, Rong
    JOURNAL OF OVARIAN RESEARCH, 2024, 17 (01)
  • [6] A New Approach to Polycystic Ovary Syndrome: The Gut Microbiota
    Yurtdas, Gamze
    Akdevelioglu, Yasemin
    JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2020, 39 (04) : 371 - 382
  • [7] Polycystic Ovary Syndrome and Endometrial Cancer: A Scoping Review of the Literature on Gut Microbiota
    Prakash, Amog
    Nourianpour, Milad
    Senok, Abiola
    Atiomo, William
    CELLS, 2022, 11 (19)
  • [8] Polycystic Ovary Syndrome and Gut Microbiota: Phenotype Matters
    Suturina, Larisa
    Belkova, Natalia
    Igumnov, Ilia
    Lazareva, Ludmila
    Danusevich, Irina
    Nadeliaeva, Iana
    Sholokhov, Leonid
    Rashidova, Maria
    Belenkaya, Lilia
    Belskikh, Aleksey
    Sharifulin, Eldar
    Ievleva, Kseniia
    Babaeva, Natalia
    Egorova, Irina
    Salimova, Madinabonu
    Kuzmin, Mikhail
    Tiumentseva, Daria
    Klimenko, Elizaveta
    Sidorova, Tuyana
    Atalyan, Alina
    LIFE-BASEL, 2023, 13 (01):
  • [9] Gut Microbiota and Polycystic Ovary Syndrome (PCOS): Understanding the Pathogenesis and the Role of Probiotics as a Therapeutic Strategy
    Salehi, Samaneh
    Allahverdy, Javad
    Pourjafar, Hadi
    Sarabandi, Khashayar
    Jafari, Seid Mahdi
    PROBIOTICS AND ANTIMICROBIAL PROTEINS, 2024, 16 (05) : 1553 - 1565
  • [10] Causal relationship between gut microbiota and polycystic ovary syndrome: a literature review and Mendelian randomization study
    Sun, Junwei
    Wang, Mingyu
    Kan, Zhisheng
    FRONTIERS IN ENDOCRINOLOGY, 2024, 15