Mendelian randomization analysis reveals the impact of physical and occupational activities on the risk of gastroesophageal reflux disease and Barrett's esophagus

被引:0
|
作者
Wan, Li [1 ]
Zuo, Hong-Zhou [2 ]
Li, De-wei [1 ,3 ]
机构
[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing, Peoples R China
[2] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China
[3] Chongqing Univ, Canc Hosp, Hepatobiliary & Pancreat Canc Ctr, Chongqing, Peoples R China
基金
中国国家自然科学基金;
关键词
Gastroesophageal reflux disease; Barrett's esophagus; physical activity; occupational activity; Mendelian randomization; GWAS; EXERCISE; WORK; ASSOCIATION; PREVALENCE;
D O I
10.1080/00365521.2023.2287416
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
BackgroundRecent studies have indicated that participating in physical activity may provide a safeguard against gastroesophageal reflux disease (GERD). Nevertheless, the precise links between physical and occupational activity and the occurrence of GERD and Barrett's esophagus (BE) are still uncertain.MethodsConducting univariate and multivariate Mendelian randomization investigations to examine the causal relationship between exposures and outcomes. Genetic variation simulation was used in randomized experiments. Data on physical and occupational activity were obtained from the UK Biobank and GWAS catalog. In the meantime, data on GERD and BE were extracted from a high quality meta-analysis.ResultsThe results of univariate Mendelian randomization analysis using multiple methods suggest a causal relationship between strenuous sports or other forms of exercise (as a protective factor) and GERD/BE. At the same time, three types of occupational related physical activities, including heavy manual or physical work, shift work and walking or standing work, are risk factors for GERD/BE and have a causal relationship with them. These results were reconfirmed through multivariate Mendelian randomization analysis, which excluding the influence of other potential confounding factors.ConclusionsThe findings indicated that strenuous sports or other forms of exercise could lower the likelihood of GERD/BE, while excessive physical strain in the workplace, prolonged periods of standing or walking, and shift work could raise the risk of GERD/BE. Acknowledging this risk and implementing suitable measures can contribute to the prevention of GERD and BE, thus mitigating the associated health burden.
引用
收藏
页码:246 / 253
页数:8
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