Neurons in the primary visual cortex of freely moving rats encode both sensory and non-sensory task variables

被引:0
作者
Zhang, Anqi [1 ,2 ,3 ]
Zador, Anthony M. [1 ]
机构
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[2] Cold Spring Harbor Lab, Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
[3] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
基金
美国国家卫生研究院;
关键词
RECEPTIVE-FIELDS; DYNAMICS; MOVEMENTS; RESPONSES;
D O I
10.1371/journal.pbio.3002384
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neurons in primary visual cortex (area V1) are strongly driven by both sensory stimuli and non-sensory events. However, although the representation of sensory stimuli has been well characterized, much less is known about the representation of non-sensory events. Here, we characterize the specificity and organization of non-sensory representations in rat V1 during a freely moving visual decision task. We find that single neurons encode diverse combinations of task features simultaneously and across task epochs. Despite heterogeneity at the level of single neuron response patterns, both visual and nonvisual task variables could be reliably decoded from small neural populations (5 to 40 units) throughout a trial. Interestingly, in animals trained to make an auditory decision following passive observation of a visual stimulus, some but not all task features could also be decoded from V1 activity. Our results support the view that even in V1-the earliest stage of the cortical hierarchy-bottom-up sensory information may be combined with top-down non-sensory information in a task-dependent manner. Neurons in primary visual cortex (area V1) are strongly driven by both sensory stimuli and nonsensory events. This study shows that during visual and auditory decisions, rat V1 represents multiple task features in an overlapping and distributed fashion, with some modulation by task demands.
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页数:26
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