Aerospace equipment has been placing greater demands on the wear resistance and fatigue strength of titanium alloys. In light of this, the research objective was to prepare a WC-10Co-4Cr coating with better performance through the utilization of the ultra-short distance high-speed oxygen fuel (HVOF) spraying process. Then the microstructure, microhardness, sliding wear, and fatigue performance of TC6 alloy reinforced with WC-10Co-4Cr coating were further explored and analyzed. The ultra-short distance HVOF spraying process was employed to suppress decarburization, resulting in a minimal amount of W2C phase in the coating. The WC-10Co-4Cr coating exhibited excellent surface characteristics, displaying minimal microcracks and a low porosity rate of 0.15 +/- 0.08%. The interface between the coating and the substrate was sharp and clean, while the TC6 alloy retained its dual structural characteristics without any microstructural changes. The microhardness of the WC-10Co-4Cr coating exhibited a remarkable value of 1172.64 HV0.025, which is 3.2 times greater than that of the substrate. The coating exhibited a noteworthy decrease in wear rate, wear depth, and wear area, indicating superior wear resistance. Additionally, a thorough examination was conducted to uncover the underlying wear mechanism of the coating under different loads. The WC-10Co-4Cr coating, which was developed through this study, shows a minimal influence on the fatigue strength of the original base material. Furthermore, a comprehensive analysis was conducted to elucidate the factors contributing to the significant fatigue life of the WC-10Co-4Cr coating.