Coumarin-based homoisoflavonoids as precursors in the synthesis of 8-heteroarylmethylcoumarins

被引：0

作者：

Myshko, Nataliia V. ^{[1
]}

Mrug, Galyna P. ^{[1
]}

Kondratyuk, Kostyantyn M. ^{[1
]}

Bondarenko, Svitlana P. ^{[2
]}

Frasinyuk, Mykhaylo S. ^{[1
,3
]}

机构：

[1] Natl Acad Sci Ukraine, VP Kukhar Inst Bioorgan Chem & Petrochem, 1 Akad Kukharya St, UA-02094 Kiev, Ukraine

[2] Natl Univ Food Technol, 68 Volodymyrska St, UA-01601 Kiev, Ukraine

[3] Enamine Ltd, 78 Winston Churchill St, UA-02094 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2023年 / 59卷 / 6-7期

关键词：

coumarins; homoisoflavonoids; pyrazoles; pyrimidines; inverse electron-demand Diels-Alder reaction; CARBONIC-ANHYDRASES; ANALOGS; 3-ARYLCOUMARINS; DERIVATIVES; ANTIOXIDANT; MECHANISM;

D O I：

10.1007/s10593-023-03216-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of homoisoflavonoids bearing 3-(het)arylcoumarin moiety were synthesized by cascade reaction of enaminones with 8-dimethyl- aminomethyl-7-hydroxy-3-(het)arylcoumarins. The further reaction of synthesized coumarin-isoflavone hybrids with bidentate nucleophiles led to the formation of substituted 7-hydroxy-8-(1H-pyrazol-4-ylmethyl)coumarins, 7-hydroxy-8-(isoxazol-4-ylmethyl)- coumarins, and 7-hydroxy-8-(pyrimidin-5-ylmethyl)coumarins.

引用

页码：456 / 464

页数：9

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