Recent Advances in Sodium Magnetic Resonance Imaging and Its Future Role in Kidney Disease

被引：6

作者：

Akbari, Alireza ^{[1
,2
]}

McIntyre, Christopher W. W. ^{[1
,2
,3
]}

机构：

[1] Western Univ, Robarts Res Inst, London, ON N6A 3K7, Canada

[2] London Hlth Sci Ctr, Lilibeth Caberto Kidney Clin Res Unit, London, ON N6A 5W9, Canada

[3] Western Univ, Dept Med Pediat & Med Biophys, London, ON N6A 3K7, Canada

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 13期

关键词：

chronic kidney disease; hypertension; inflammation; sodium MRI; skin; heart; kidney; corticomedullary gradient; myocardium; functional sodium MRI; DECOMPENSATED HEART-FAILURE; 11TH CONSENSUS CONFERENCE; IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS; LEFT-VENTRICULAR HYPERTROPHY; ENHANCER-BINDING PROTEIN; INSULIN-RESISTANCE; BLOOD-PRESSURE; TISSUE SODIUM; CARDIOVASCULAR-DISEASE; NA+ STORAGE;

D O I：

10.3390/jcm12134381

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sodium imbalance is a hallmark of chronic kidney disease (CKD). Excess tissue sodium in CKD is associated with hypertension, inflammation, and cardiorenal disease. Sodium magnetic resonance imaging (Na-23 MRI) has been increasingly utilized in CKD clinical trials especially in the past few years. These studies have demonstrated the association of excess sodium tissue accumulation with declining renal function across whole CKD spectrum (early- to end-stage), biomarkers of systemic inflammation, and cardiovascular dysfunction. In this article, we review recent advances of Na-23 MRI in CKD and discuss its future role with a focus on the skin, the heart, and the kidney itself.

引用

页数：16

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