ROS mediated pyroptosis-M1 polarization crosstalk participates in inflammation of chicken liver induced by bisphenol A and selenium deficiency
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作者:
Shi, Xu
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Shi, Xu
[1
]
Xu, Tong
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Xu, Tong
[1
]
Li, Xiaojing
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Northeast Agr Univ, Coll Anim Sci & Technol, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Li, Xiaojing
[2
]
Sun, Xinyue
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Sun, Xinyue
[1
]
Zhang, Wenyue
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Zhang, Wenyue
[1
]
Liu, Xiaojing
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Liu, Xiaojing
[1
]
Wang, Yuqi
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Wang, Yuqi
[1
]
Zhang, Yilei
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Zhang, Yilei
[1
]
Xu, Shiwen
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Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Northeast Agr Univ, Coll Vet Med, Key Lab Prov Educ Dept Heilongjiang Common Anim Di, Harbin 150030, Peoples R China
Northeast Agr Univ, Coll Life Sci, Lab Embryo Biotechnol, Harbin 150030, Peoples R ChinaNortheast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
Xu, Shiwen
[1
,3
,4
]
机构:
[1] Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
[2] Northeast Agr Univ, Coll Anim Sci & Technol, Harbin 150030, Peoples R China
[3] Northeast Agr Univ, Coll Vet Med, Key Lab Prov Educ Dept Heilongjiang Common Anim Di, Harbin 150030, Peoples R China
[4] Northeast Agr Univ, Coll Life Sci, Lab Embryo Biotechnol, Harbin 150030, Peoples R China
The earth's natural environmental factors and man-made industrial pollution often lead to the co-occurrence of environmental pathogenic factors and malnutrition. Bisphenol A (BPA) is a serious environmental endocrine disruptor, and its exposure can cause liver tissue damage. Selenium (Se) deficiency is a worldwide problem that afflicts thousands of people, and Se deficiency can cause M1/M2 imbalance. In addition, the crosstalk between hepatocyte and immune cell is closely related to the occurrence of hepatitis. Therefore, this study found for the first time that the combined exposure of BPA and Se deficiency caused liver pyroptosis and M1 polarization through ROS, and the crosstalk between pyroptosis and M1 polarization aggravated liver inflammation in chicken. In this study, the BPA or/and Se deficiency chicken liver, single and co-culture model of LMH and HD11 cells were established. The results displayed that BPA or Se deficiency induced liver inflammation accompanied by pyroptosis and M1 polarization through oxidative stress, and increased expressions of chemokines (CCL4, CCL17, CCL19, and MIF) and inflammatory factors (IL-1 & beta; and TNF-& alpha;). The vitro experiments further verified the above changes and showed that LMH pyroptosis promoted M1 polarization of HD11 cells, and vice versa. NAC counteracted pyroptosis and M1 polarization caused by BPA and low-Se, reducing the release of inflammatory factors. In brief, BPA and Se deficiency treatment can exacerbate liver inflammation by increasing oxidative stress to induce pyroptosis and M1 polarization.
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Northeastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R ChinaNortheastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R China
Bao, Bo-wen
Kang, Zibo
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Anim Dis Prevent & Control Ctr Heilongjiang Prov, Harbin 150000, Peoples R ChinaNortheastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R China
Kang, Zibo
Zhang, Yu
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Northeastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R ChinaNortheastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R China
Zhang, Yu
Li, Kan
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Northeastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R ChinaNortheastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R China
Li, Kan
Xu, Ran
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Northeastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R ChinaNortheastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R China
Xu, Ran
Guo, Meng-yao
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Northeastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R ChinaNortheastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R China
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Univ Missouri, Biol Sci, Columbia, MO 65211 USA
US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Bhandari, Ramji K.
Deem, Sharon L.
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St Louis Zoo, Inst Conservat Med, St Louis, MO 63110 USA
Univ Missouri, Vet Clin Med, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Deem, Sharon L.
Holliday, Dawn K.
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Westminster Coll, Dept Biol & Environm Sci, Fulton, MO 65251 USA
Univ Missouri, Dept Pathol & Anat Sci, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Holliday, Dawn K.
Jandegian, Caitlin M.
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US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USA
St Louis Zoo, Inst Conservat Med, St Louis, MO 63110 USA
Univ Missouri, Masters Publ Hlth Program, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Jandegian, Caitlin M.
Kassotis, Christopher D.
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Univ Missouri, Biol Sci, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Kassotis, Christopher D.
Nagel, Susan C.
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Univ Missouri, Biol Sci, Columbia, MO 65211 USA
Univ Missouri, Obstet Gynecol & Womens Hlth, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Nagel, Susan C.
Tillitt, Donald E.
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US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Tillitt, Donald E.
Saal, Frederick S. Vom
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Univ Missouri, Biol Sci, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Saal, Frederick S. Vom
Rosenfeld, Cheryl S.
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Univ Missouri, Biomed Sci, Columbia, MO 65211 USA
Univ Missouri, Bond Life Sci Ctr, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
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Henan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R China
China Univ Min & Technol, Sch Environm Sci & Spatial Informat, Xuzhou 221116, Jiangsu, Peoples R ChinaHenan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R China
Gu, Deming
Song, Zhongxian
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Henan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R ChinaHenan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R China
Song, Zhongxian
Kang, Haiyan
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Henan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R ChinaHenan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R China
Kang, Haiyan
Mao, Yanli
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Henan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R ChinaHenan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R China
Mao, Yanli
Feng, Qiyan
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China Univ Min & Technol, Sch Environm Sci & Spatial Informat, Xuzhou 221116, Jiangsu, Peoples R ChinaHenan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R China
机构:
Northeastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R ChinaNortheastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R China
Bao, Bo-wen
Kang, Zibo
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机构:
Anim Dis Prevent & Control Ctr Heilongjiang Prov, Harbin 150000, Peoples R ChinaNortheastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R China
Kang, Zibo
Zhang, Yu
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Northeastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R ChinaNortheastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R China
Zhang, Yu
Li, Kan
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Li, Kan
Xu, Ran
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Northeastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R ChinaNortheastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R China
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Guo, Meng-yao
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Northeastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R ChinaNortheastern Agr Univ, Coll Vet Med, Harbin 150000, Peoples R China
机构:
Univ Missouri, Biol Sci, Columbia, MO 65211 USA
US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Bhandari, Ramji K.
Deem, Sharon L.
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Zoo, Inst Conservat Med, St Louis, MO 63110 USA
Univ Missouri, Vet Clin Med, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Deem, Sharon L.
Holliday, Dawn K.
论文数: 0引用数: 0
h-index: 0
机构:
Westminster Coll, Dept Biol & Environm Sci, Fulton, MO 65251 USA
Univ Missouri, Dept Pathol & Anat Sci, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Holliday, Dawn K.
Jandegian, Caitlin M.
论文数: 0引用数: 0
h-index: 0
机构:
US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USA
St Louis Zoo, Inst Conservat Med, St Louis, MO 63110 USA
Univ Missouri, Masters Publ Hlth Program, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Jandegian, Caitlin M.
Kassotis, Christopher D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Biol Sci, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Kassotis, Christopher D.
Nagel, Susan C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Biol Sci, Columbia, MO 65211 USA
Univ Missouri, Obstet Gynecol & Womens Hlth, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Nagel, Susan C.
Tillitt, Donald E.
论文数: 0引用数: 0
h-index: 0
机构:
US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Tillitt, Donald E.
Saal, Frederick S. Vom
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Biol Sci, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
Saal, Frederick S. Vom
Rosenfeld, Cheryl S.
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h-index: 0
机构:
Univ Missouri, Biomed Sci, Columbia, MO 65211 USA
Univ Missouri, Bond Life Sci Ctr, Columbia, MO 65211 USAUniv Missouri, Biol Sci, Columbia, MO 65211 USA
机构:
Henan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R China
China Univ Min & Technol, Sch Environm Sci & Spatial Informat, Xuzhou 221116, Jiangsu, Peoples R ChinaHenan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R China
Gu, Deming
Song, Zhongxian
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Henan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R ChinaHenan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R China
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Henan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R ChinaHenan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R China
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Henan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R ChinaHenan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R China
Mao, Yanli
Feng, Qiyan
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China Univ Min & Technol, Sch Environm Sci & Spatial Informat, Xuzhou 221116, Jiangsu, Peoples R ChinaHenan Univ Urban Construct, Fac Environm & Municipal Engn, Henan Key Lab Water Pollut Control & Rehabil Tech, Pingdingshan 467036, Peoples R China