ROS mediated pyroptosis-M1 polarization crosstalk participates in inflammation of chicken liver induced by bisphenol A and selenium deficiency

被引:26
作者
Shi, Xu [1 ]
Xu, Tong [1 ]
Li, Xiaojing [2 ]
Sun, Xinyue [1 ]
Zhang, Wenyue [1 ]
Liu, Xiaojing [1 ]
Wang, Yuqi [1 ]
Zhang, Yilei [1 ]
Xu, Shiwen [1 ,3 ,4 ]
机构
[1] Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China
[2] Northeast Agr Univ, Coll Anim Sci & Technol, Harbin 150030, Peoples R China
[3] Northeast Agr Univ, Coll Vet Med, Key Lab Prov Educ Dept Heilongjiang Common Anim Di, Harbin 150030, Peoples R China
[4] Northeast Agr Univ, Coll Life Sci, Lab Embryo Biotechnol, Harbin 150030, Peoples R China
关键词
BPA; Se deficiency; Chicken; Liver inflammation; Pyroptosis-M1 polarization crosstalk; KUPFFER CELLS; EXPOSURE; INHIBITION; MECHANISMS; ANALOGS;
D O I
10.1016/j.envpol.2023.121392
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The earth's natural environmental factors and man-made industrial pollution often lead to the co-occurrence of environmental pathogenic factors and malnutrition. Bisphenol A (BPA) is a serious environmental endocrine disruptor, and its exposure can cause liver tissue damage. Selenium (Se) deficiency is a worldwide problem that afflicts thousands of people, and Se deficiency can cause M1/M2 imbalance. In addition, the crosstalk between hepatocyte and immune cell is closely related to the occurrence of hepatitis. Therefore, this study found for the first time that the combined exposure of BPA and Se deficiency caused liver pyroptosis and M1 polarization through ROS, and the crosstalk between pyroptosis and M1 polarization aggravated liver inflammation in chicken. In this study, the BPA or/and Se deficiency chicken liver, single and co-culture model of LMH and HD11 cells were established. The results displayed that BPA or Se deficiency induced liver inflammation accompanied by pyroptosis and M1 polarization through oxidative stress, and increased expressions of chemokines (CCL4, CCL17, CCL19, and MIF) and inflammatory factors (IL-1 & beta; and TNF-& alpha;). The vitro experiments further verified the above changes and showed that LMH pyroptosis promoted M1 polarization of HD11 cells, and vice versa. NAC counteracted pyroptosis and M1 polarization caused by BPA and low-Se, reducing the release of inflammatory factors. In brief, BPA and Se deficiency treatment can exacerbate liver inflammation by increasing oxidative stress to induce pyroptosis and M1 polarization.
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页数:12
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共 57 条
  • [1] [Anonymous], 1999, INT J EXP PATHOL, V158, P1913
  • [2] Selenium Deficiency Leads to Reduced Skeletal Muscle Cell Differentiation by Oxidative Stress in Mice
    Bao, Bo-wen
    Kang, Zibo
    Zhang, Yu
    Li, Kan
    Xu, Ran
    Guo, Meng-yao
    [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 2023, 201 (04) : 1878 - 1887
  • [3] Assessment of dietary exposure to bisphenol A in the French population with a special focus on risk characterisation for pregnant French women
    Bemrah, Nawel
    Jean, Julien
    Riviere, Gilles
    Sanaa, Moez
    Leconte, Stephane
    Bachelot, Morgane
    Deceuninck, Yoann
    Le Bizec, Bruno
    Dauchy, Xavier
    Roudot, Alain-Claude
    Camel, Valerie
    Grob, Konrad
    Feidt, Cyril
    Picard-Hagen, Nicole
    Badot, Pierre-Marie
    Foures, Franck
    Leblanc, Jean-Charles
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2014, 72 : 90 - 97
  • [4] Not Hard to Swallow-Understanding Endothelial-Fibroblast Crosstalk in Eosinophilic Esophagitis
    Beveridge, Claire A.
    Gabbard, Scott
    Rieder, Florian
    [J]. GASTROENTEROLOGY, 2022, 162 (02) : 390 - 392
  • [5] Effects of the environmental estrogenic contaminants bisphenol A and 17α-ethinyl estradiol on sexual development and adult behaviors in aquatic wildlife species
    Bhandari, Ramji K.
    Deem, Sharon L.
    Holliday, Dawn K.
    Jandegian, Caitlin M.
    Kassotis, Christopher D.
    Nagel, Susan C.
    Tillitt, Donald E.
    Saal, Frederick S. Vom
    Rosenfeld, Cheryl S.
    [J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY, 2015, 214 : 195 - 219
  • [6] Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis
    Chi, Qianru
    Zhang, Qing
    Lu, Yiming
    Zhang, Yiming
    Xu, Shiwen
    Li, Shu
    [J]. REDOX BIOLOGY, 2021, 44
  • [8] Selenium Deficiency Caused Fibrosis as an Oxidative Stress-induced Inflammatory Injury in the Lungs of Mice
    Fu, Yu-xin
    Wang, Yi-bo
    Bu, Qing-wei
    Guo, Meng-yao
    [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 2023, 201 (03) : 1286 - 1300
  • [9] Inhibition of male chick phenotypes and spermatogenesis by Bisphenol-A
    Furuya, M
    Adachi, K
    Kuwahara, S
    Ogawa, K
    Tsukamoto, Y
    [J]. LIFE SCIENCES, 2006, 78 (15) : 1767 - 1776
  • [10] Occurrence, Profiles and Ecological Risk of Bisphenol Analogues in a Municipal Sewage Treatment Plant
    Gu, Deming
    Song, Zhongxian
    Kang, Haiyan
    Mao, Yanli
    Feng, Qiyan
    [J]. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2021, 106 (06) : 1044 - 1049