Gentian Violet Inhibits Cell Proliferation through Induction of Apoptosis in Ovarian Cancer Cells

被引：3
|
作者：
Choi, Min Sung [1 ]
Kim, Ji Hyeon [2 ]
Lee, Chae Yeon [2 ]
Lee, Yul Min [1 ]
Lee, Sukmook [1 ,2 ,3 ]
Chang, Ha Kyun [4 ]
Kim, Hyun Jung [1 ,2 ,3 ]
Heo, Kyun [1 ,2 ,3 ]
机构：
[1] Kookmin Univ, Dept Biopharmaceut Chem, Seoul 02707, South Korea
[2] Kookmin Univ, Sch Appl Chem, Seoul 02707, South Korea
[3] Kookmin Univ, Antibody Res Inst, Seoul 02707, South Korea
[4] Korea Univ, Ansan Hosp, Coll Med, Dept Obstet & Gynecol, Ansan 15855, South Korea
来源：
BIOMEDICINES | 2023年 / 11卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
gentian violet; ovarian cancer; apoptosis; TUMOR-GROWTH; SUPPRESSION; FAMILY; P53;
D O I：
10.3390/biomedicines11061657
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gentian violet (GV) is known to have antibacterial and antifungal effects, but recent studies have demonstrated its inhibitory effects on the growth of several types of cancer cells. Here, we investigated the anticancer efficacy of GV in ovarian cancer cells. GV significantly reduced the proliferation of OVCAR8, SKOV3, and A2780 cells. Results of transferase dUTP nick and labeling (TUNEL) assay and Western blot assay indicated that the inhibitory effect of GV on ovarian cancer cells was due to the induction of apoptosis. Moreover, GV significantly increased reactive oxygen species (ROS) and upregulated the expression of p53, PUMA, BAX, and p21, critical components for apoptosis induction, in ovarian cancer cells. Our results suggest that GV is a novel antiproliferative agent and is worthy of exploration as a potential therapeutic agent for ovarian cancer.
引用
收藏
页数：10
相关论文
共 50 条
  • [41] Pterostilbene Inhibits Colon Cancer through Induction of Apoptosis
    Alosi, J. A.
    Schneider, J. G.
    McFadden, D. W.
    ANNALS OF SURGICAL ONCOLOGY, 2009, 16 : 40 - 40
  • [42] Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells
    Choi, Myoung Suk
    Oh, Ju Hoon
    Kim, Sun Mi
    Jung, Hai Young
    Yoo, Hwan Soo
    Lee, Yong Moon
    Moon, Dong Cheul
    Han, Sang Bae
    Hong, Jin Tae
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2009, 34 (05) : 1221 - 1230
  • [43] Cepharanthine inhibits proliferation of cancer cells by inducing apoptosis
    Furusawa, S
    Wu, JH
    Fujimura, T
    Nakano, S
    Nemoto, S
    Takayanagi, M
    Sasaki, K
    Takayanagi, Y
    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, 1998, 20 (02): : 87 - 97
  • [44] Luteolin inhibits proliferation of human glioblastoma cells via induction of cell cycle arrest and apoptosis
    Tsai, Yu-Duan
    Chen, Han-Jung
    Hsu, Hsia-Fen
    Lu, Kang
    Liang, Cheng-Loong
    Liliang, Po-Chou
    Wang, Kuo-Wei
    Wang, Hao-Kuang
    Wang, Chao-Ping
    Houng, Jer-Yiing
    JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS, 2013, 44 (06) : 837 - 845
  • [45] Saikosaponin-d inhibits proliferation of human undifferentiated thyroid carcinoma cells through induction of apoptosis and cell cycle arrest
    Liu, R. -Y.
    Li, J. -P.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2014, 18 (17) : 2435 - 2443
  • [46] Effects of trastuzumab on the proliferation and apoptosis of ovarian cancer cells
    Cong, J.
    Liu, R.
    Hou, J.
    Wang, X.
    Jiang, H.
    Wang, J.
    NEOPLASMA, 2019, 66 (02) : 240 - 244
  • [47] A human prolactin antagonist, hPRL-G129R, inhibits breast cancer cell proliferation through induction of apoptosis
    Chen, WY
    Ramamoorthy, P
    Chen, NY
    Sticca, R
    Wagner, TE
    CLINICAL CANCER RESEARCH, 1999, 5 (11) : 3583 - 3593
  • [48] Oncogene miR-934 promotes ovarian cancer cell proliferation and inhibits cell apoptosis through targeting BRMS1L
    Hu, Y.
    Zhang, Q.
    Cui, J.
    Liao, Z-J
    Jiao, M.
    Zhang, Y-B
    Guo, Y-H
    Gao, Y-M
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (13) : 5595 - 5602
  • [49] Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells
    Wen, Fang
    Wu, Zhang-Ying
    Nie, Lei
    Zhang, Qi-Zhu
    Qin, Yuan-Kun
    Zhou, Zun-Iun
    Wu, Jin-Jian
    Zhao, Xing
    Tan, Jun
    Sawmiller, Darrell
    Zi, Dan
    BIOSCIENCE REPORTS, 2019, 39
  • [50] Fucoxanthin Inhibits Cell Proliferation and Stimulates Apoptosis through Downregulation of PI3K/AKT/mTOR Signaling Pathway in Human Ovarian Cancer Cells
    Li, Yan
    Tao, Leisi
    Bao, Lei
    Chinnathambi, Arunachalam
    Alharbi, Sulaiman Ali
    Cui, Jianying
    PHARMACOGNOSY MAGAZINE, 2020, 16 (69) : 311 - 316
12345