Healthcare professionals' knowledge, confidence and perceptions of pharmacogenomics in primary care and pain management

被引:6
作者
Behr, Matthew P. [1 ]
Gammal, Roseann S. [1 ]
Matthews, Michele L. [1 ,2 ]
Wang, Victor C. [3 ]
机构
[1] Massachusetts Coll Pharm & Hlth Sci, Dept Pharm Practice, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Pain Management Ctr, Boston, MA 02115 USA
[3] Brigham & Womens Hosp, Dept Neurol, Dept Anesthesia Perioperat & Pain Med, Boston, MA 02115 USA
关键词
pain management; personalized patient care plan; pharmacogenomics; primary care; survey; PHYSICIANS; SUPPORT;
D O I
10.2217/pgs-2023-0028
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Aim: To assess knowledge, confidence and perceptions of healthcare professionals specializing in primary care and pain management at Brigham and Women's Hospital, related to clinical pharmacogenomics (PGx). Methods: A 25-question online survey was distributed to 328 Brigham and Women's Hospital clinicians for analysis. Results: Thirty-four clinicians completed the survey. Respondents had minimal experience with PGx and limited awareness of PGx resources. Although respondents expressed belief that PGx has utility to improve medication-related patient outcomes, many lack confidence to apply PGx results to their practice. For clinical drug-gene questions relevant to primary care and/or pain management, respondents scored poorly. Conclusion: More clinician education is needed for appropriate utilization of PGx in clinical practice as it pertains to primary care and pain management.
引用
收藏
页码:371 / 379
页数:9
相关论文
共 24 条
[1]   Ethiopian health care professionals' knowledge, attitude, and interests toward pharmacogenomics [J].
Abdela, Ousman Abubeker ;
Bhagavathula, Akshaya Srikanth ;
Gebreyohannes, Eyob Alemayehu ;
Tegegn, Henok Getachew .
PHARMACOGENOMICS & PERSONALIZED MEDICINE, 2017, 10 :279-285
[2]  
Center for Drug Evaluation and Research US FDA, 2022, TABLE PHARMACOGENOMI
[3]   Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy [J].
Crews, Kristine R. ;
Monte, Andrew A. ;
Huddart, Rachel ;
Caudle, Kelly E. ;
Kharasch, Evan D. ;
Gaedigk, Andrea ;
Dunnenberger, Henry M. ;
Leeder, J. Steven ;
Callaghan, John T. ;
Samer, Caroline Flora ;
Klein, Teri E. ;
Haidar, Cyrine E. ;
Van Driest, Sara L. ;
Ruano, Gualberto ;
Sangkuhl, Katrin ;
Cavallari, Larisa H. ;
Muller, Daniel J. ;
Prows, Cynthia A. ;
Nagy, Mohamed ;
Somogyi, Andrew A. ;
Skaar, Todd C. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2021, 110 (04) :888-896
[4]   Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers [J].
Dunnenberger, Henry M. ;
Crews, Kristine R. ;
Hoffman, James M. ;
Caudle, Kelly E. ;
Broeckel, Ulrich ;
Howard, Scott C. ;
Hunkler, Robert J. ;
Klein, Teri E. ;
Evans, William E. ;
Relling, Mary V. .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55, 2015, 55 :89-+
[5]   Expanding evidence leads to new pharmacogenomics payer coverage [J].
Empey, Philip E. ;
Pratt, Victoria M. ;
Hoffman, James M. ;
Caudle, Kelly E. ;
Klein, Teri E. .
GENETICS IN MEDICINE, 2021, 23 (05) :830-832
[6]   Documenting Pharmacogenomic Test Results in Electronic Health Records: Practical Considerations for Primary Care Teams [J].
Gammal, Roseann S. ;
Berenbrok, Lucas A. ;
Empey, Philip E. ;
Massart, Mylynda B. .
JOURNAL OF PERSONALIZED MEDICINE, 2021, 11 (12)
[7]   Ready or not, here it comes: Direct-to-consumer pharmacogenomic testing and its implications for community pharmacists [J].
Gammal, Roseann S. ;
Mayes, Jason ;
Caudle, Kelly E. .
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION, 2019, 59 (05) :646-650
[8]  
Guidelines, 2021, GUIDELINES
[9]   Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants: 2016 Update [J].
Hicks, J. K. ;
Sangkuhl, K. ;
Swen, J. J. ;
Ellingrod, V. L. ;
Muller, D. J. ;
Shimoda, K. ;
Bishop, J. R. ;
Kharasch, E. D. ;
Skaar, T. C. ;
Gaedigk, A. ;
Dunnenberger, H. M. ;
Klein, T. E. ;
Caudle, K. E. ;
Stingl, J. C. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2017, 102 (01) :37-44
[10]   Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors [J].
Hicks, J. K. ;
Bishop, J. R. ;
Sangkuhl, K. ;
Mueller, D. J. ;
Ji, Y. ;
Leckband, S. G. ;
Leeder, J. S. ;
Graham, R. L. ;
Chiulli, D. L. ;
LLerena, A. ;
Skaar, T. C. ;
Scott, S. A. ;
Stingl, J. C. ;
Klein, T. E. ;
Caudle, K. E. ;
Gaedigk, A. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2015, 98 (02) :127-134