Electrospun silk fibroin/polyethylene oxide composite scaffolds with strontium or copper-doped hollow bioactive glass nanospheres for pH-triggered sustained drug release

被引：2

作者：

Li, Ya ^{[1
,3
]}

Wang, Yue ^{[1
]}

Zhang, Lixiang ^{[1
]}

Ding, Xinbo ^{[1
]}

Liu, Tao ^{[1
,2
]}

Qiu, Qiaohua ^{[1
]}

Jiang, Zhixin ^{[3
]}

机构：

[1] Zhejiang Sci Tech Univ, Coll Text Sci & Engn, Int Silk Coll, Hangzhou 310018, Peoples R China

[2] Zhejiang Sci Tech Univ, Keyi Coll, Shaoxing 312369, Peoples R China

[3] Laimei Technol Co Ltd, Huzhou 313109, Zhejiang, Peoples R China

来源：

MATERIALS LETTERS | 2023年 / 336卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Composite materials; Structural; Sr/Cu-doping; Bioactivity; Drug delivery; FABRICATION; BEHAVIOR;

D O I：

10.1016/j.matlet.2023.133881

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Organic/inorganic hybrid biomaterials based on polymeric nano-composites constructed from mixture of biodegradable polymeric matrices and bioactive inorganic substrates have been highly attractive owing to their efficient tissue engineering applications. Herein we reported, for the first time, electrospun silk fibroin/polyethylene oxide (SF/PEO) scaffolds incorporated with appropriate strontium or copper-doped hollow bioactive glass nanospheres (Sr/Cu-HBGNs) loading with vancomycin hydrochloride (VAN) were prepared and their use as pH-sensitive drug nano-carriers to extend the duration of drug release were reported as well. In addition, the excellent apatite-formation ability of Sr/Cu-introduced nanocomposites improved the bioactivity of the related scaffolds.

引用

页数：4