In 2014, UNAIDS outlined the 90-90-90 treatment targets. The "fourth 90" reflects the need to focus on optimising quality of life (HRQoL) in people living with HIV. Using a sample of non-heterosexual males in Melbourne, Australia, we aimed to assess HRQoL differences between HIV-positive and HIV-negative individuals, and identify factors that predict HRQoL both at baseline and after three years of follow up. Clinical information and patient-reported outcomes incorporating the Assessing Quality of Life-6D scale were collected at baseline and at three years. Sixty-two HIV-positive cases (antiretroviral therapy naive at baseline) and 48 controls were enrolled. Results were compared between cases and controls at baseline, three-year follow-up, and between timepoints. HRQoL was significantly lower in cases compared to controls (83.5 (IQR 77.2-88.6) vs 87.3 (IQR 82.1-91.8), p = 0.022) at baseline, with increased depression and anxiety associated with reduced HRQoL in multivariate analysis. Mental health in cases improved between timepoints (75.0 (IQR 56.3-81.3) to 81.3 (IQR 62.5-81.3), p = 0.0428). No differences between the HRQoL of cases and controls were observed at three years. Increased mental health support may be required at commencement of antiretroviral therapy to enable similar levels of HRQoL between HIV-positive and HIV-negative individuals to be achieved.
机构:
Infect Dis AIDS & Clin Immunol Res Ctr, 16 Al Kazbegi Ave, Tbilisi 0160, GeorgiaInfect Dis AIDS & Clin Immunol Res Ctr, 16 Al Kazbegi Ave, Tbilisi 0160, Georgia
Karkashadze, Ekaterine
Gates, Margaret A.
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SUNY Albany, Sch Publ Hlth, Dept Epidemiol & Biostat, Albany, NY USAInfect Dis AIDS & Clin Immunol Res Ctr, 16 Al Kazbegi Ave, Tbilisi 0160, Georgia
Gates, Margaret A.
Chkhartishvili, Nikoloz
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Infect Dis AIDS & Clin Immunol Res Ctr, 16 Al Kazbegi Ave, Tbilisi 0160, GeorgiaInfect Dis AIDS & Clin Immunol Res Ctr, 16 Al Kazbegi Ave, Tbilisi 0160, Georgia
Chkhartishvili, Nikoloz
DeHovitz, Jack
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Suny Downstate Med Ctr, Dept Med, Brooklyn, NY 11203 USAInfect Dis AIDS & Clin Immunol Res Ctr, 16 Al Kazbegi Ave, Tbilisi 0160, Georgia
DeHovitz, Jack
Tsertsvadze, Tengiz
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Infect Dis AIDS & Clin Immunol Res Ctr, 16 Al Kazbegi Ave, Tbilisi 0160, GeorgiaInfect Dis AIDS & Clin Immunol Res Ctr, 16 Al Kazbegi Ave, Tbilisi 0160, Georgia
机构:
La Trobe Univ, Australian Res Ctr Sex Hlth & Soc, Bundoora, Vic 3086, AustraliaLa Trobe Univ, Australian Res Ctr Sex Hlth & Soc, Bundoora, Vic 3086, Australia
Thepsourinthone, Jack
Norman, Thomas
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La Trobe Univ, Australian Res Ctr Sex Hlth & Soc, Bundoora, Vic 3086, AustraliaLa Trobe Univ, Australian Res Ctr Sex Hlth & Soc, Bundoora, Vic 3086, Australia
Norman, Thomas
Murphy, Dean
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La Trobe Univ, Australian Res Ctr Sex Hlth & Soc, Bundoora, Vic 3086, AustraliaLa Trobe Univ, Australian Res Ctr Sex Hlth & Soc, Bundoora, Vic 3086, Australia
Murphy, Dean
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Power, Jennifer
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV,
2025,
37
(03):
: 435
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