Solid-Liquid Equilibrium Modeling and Analysis of Acetylcysteine in 12 Pure Solvents

被引：1
作者：
Shu, Junning [1 ]
Li, Peizhou [1 ]
Huang, Xin [2 ,3 ]
Cheng, Xiaowei [1 ]
Wang, Na [2 ,3 ]
Hao, Hongxun [1 ,2 ,3 ]
机构：
[1] Hainan Univ, Sch Chem Engn & Technol, Hainan Prov Key Lab Fine Chem, Haikou 570228, Hainan, Peoples R China
[2] Tianjin Univ, Natl Engn Res Ctr Ind Crystallizat Technol, Sch Chem Engn & Technol, Tianjin 30072, Peoples R China
[3] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2023年 / 68卷 / 12期
基金：
海南省自然科学基金;
关键词：
DISSOLUTION THERMODYNAMIC PROPERTIES; GLUTARIC ACID; SOLUBILITY; PARAMETERS; MIXTURES; WATER;
D O I：
10.1021/acs.jced.3c00458
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
In this work, the solubility of acetylcysteine in 12 pure solvents (water, methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, dimethylformamide, formamide, ethylene glycol, dimethylacetamide, and dimethyl sulfoxide) was determined using a dynamic method over the temperature range from 278.15 to 323.15 K. The results indicate that the solubility of acetylcysteine increases with increases in temperature. Furthermore, the solubility of acetylcysteine in alcohols decreases with decreasing polarity. These solubility data were compared with predictions generated using the modified Apelblat equation, the lambda h equation, the Wilson model, and the NRTL model. The modified Apelblat equation generated the most accurate values.
引用
收藏
页码：3435 / 3443
页数：9
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