Systemic Treatment for Brain Metastasis and Leptomeningeal Disease in Breast Cancer Patients

被引：4

作者：

Puri, Sushant ^{[1
,2
]}

Chaudhry, Amina ^{[3
]}

Bayable, Asnakech ^{[2
]}

Ganesh, Ashwin ^{[4
]}

Daher, Ahmad ^{[4
,5
]}

Gadi, Vijayakrishna K. ^{[3
,5
]}

Maraka, Stefania ^{[4
]}

机构：

[1] NCI, NIH, Neurooncol Branch, Bethesda, MD USA

[2] Johns Hopkins Univ Hosp, Sidney Kimmel Canc Ctr, Dept Oncol, Baltimore, MD USA

[3] Univ Illinois, Dept Med, Div Hematol & Oncol, Chicago, IL USA

[4] Univ Illinois, Dept Neurology& Rehabil, 912 South Wood St 174N m-c, Chicago, IL 60612 USA

[5] Univ Illinois, Canc Ctr, Translat Oncol Program, Chicago, IL USA

来源：

CURRENT ONCOLOGY REPORTS | 2023年 / 25卷 / 12期

关键词：

Breast cancer; Brain metastases; Leptomeningeal disease; Systemic treatment; HER2+breast cancer; Triple negative breast cancer; PHASE-II TRIAL; LAPATINIB PLUS CAPECITABINE; TRASTUZUMAB EMTANSINE; OPEN-LABEL; SACITUZUMAB GOVITECAN; CEREBROSPINAL-FLUID; TUMOR SUBTYPE; SOLID TUMORS; SINGLE-ARM; TEMOZOLOMIDE;

D O I：

10.1007/s11912-023-01468-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose of ReviewBreast cancer with brain metastasis (BCBM) and leptomeningeal disease (LMD) are important clinical problems. Traditionally, patients with metastases to the brain and meninges were excluded from clinical trials; hence, robust, evidence-based treatment recommendations are lacking. In this review, we outline the systemic treatment options and ongoing clinical trials.Recent FindingsSeveral recent studies have added to the systemic treatment options available. Antibody-drug conjugates have changed the therapeutic landscape. Combination treatment modalities that target multiple mechanisms including disruption of the blood brain barrier are increasingly being studied.SummaryBreast cancer with brain metastases and LMD is a heterogenous disease. While the prognosis remains grim, with more systemic treatment options, patients with BCBM are now living longer. Many ongoing clinical trials hold promise to further improve outcomes.

引用

页码：1419 / 1430

页数：12

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