Oxygen releasing patches based on carbohydrate polymer and protein hydrogels for diabetic wound healing: A review

被引：28

作者：

Al Mamun, Abdulla ^{[1
,2
]}

Ullah, Asad ^{[1
,2
]}

Chowdhury, Muhammad E. H. ^{[3
]}

Marei, Hany E. ^{[4
]}

Madappura, Alakananda Parassini ^{[1
,2
]}

Hassan, Mahbub ^{[5
]}

Rizwan, Muhammad ^{[6
]}

Gomes, Vincent G. ^{[5
,7
]}

Amirfazli, Alidad ^{[8
]}

Hasan, Anwarul ^{[1
,2
]}

机构：

[1] Qatar Univ, Dept Mech & Ind Engn, Doha, Qatar

[2] Qatar Univ, Biomed Res Ctr BRC, Doha, Qatar

[3] Qatar Univ, Dept Elect Engn, Doha, Qatar

[4] Mansoura Univ, Fac Vet Med, Dept Cytol & Histol, Mansoura, Egypt

[5] Univ Sydney, Sch Chem & Biomol Engn, Sydney, NSW 2006, Australia

[6] Michigan Technol Univ, Hougton, MI USA

[7] Univ Sydney, Sydney Nano Inst, Sydney, NSW 2006, Australia

[8] York Univ, Dept Mech Engn, Toronto, ON, Canada

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2023年 / 250卷

关键词：

Composite materials; Hydrogels; Diabetic wound healing; Oxygen releasing materials; HYPERBARIC-OXYGEN; CHITOSAN HYDROGEL; PHOTOSYNTHETIC BIOMATERIALS; PERFLUOROCARBON EMULSIONS; CELL-SURVIVAL; MANAGEMENT; DELIVERY; DIFFERENTIATION; ANGIOGENESIS; SCAFFOLDS;

D O I：

10.1016/j.ijbiomac.2023.126174

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetic wounds are among the major healthcare challenges, consuming billions of dollars of resources and resulting in high numbers of morbidity and mortality every year. Lack of sufficient oxygen supply is one of the most dominant causes of impaired healing in diabetic wounds. Numerous clinical and experimental studies have demonstrated positive outcomes as a result of delivering oxygen at the diabetic wound site, including enhanced angiogenesis, antibacterial and cell proliferation activities. However, prolonged and sustained delivery of oxygen to improve the wound healing process has remained a major challenge due to rapid release of oxygen from oxygen sources and limited penetration of oxygen into deep skin tissues. Hydrogels made from sugar-based polymers such as chitosan and hyaluronic acid, and proteins such as gelatin, collagen and hemoglobin have been widely used to deliver oxygen in a sustained delivery mode. This review presents an overview of the recent advances in oxygen releasing hydrogel based patches as a therapeutic modality to enhance diabetic wound healing. Various types of oxygen releasing wound healing patch have been discussed along with their fabrication method, release profile, cytocompatibility andin vivo results. We also briefly discuss the challenges and prospects related to the application of oxygen releasing biomaterials as wound healing therapeutics.

引用

页数：17

共 140 条

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