A Nature-Inspired Versatile Bio-Adhesive

被引：11
作者：
Chen, Mingxia [1 ]
Chen, Taijun [2 ]
Bai, Jiafan [1 ]
He, Siyuan [1 ]
Luo, Minyue [1 ]
Zeng, Yili [1 ]
Peng, Wenzhen [3 ]
Zhao, Yuancong [1 ]
Wang, Jianxin [1 ]
Zhu, Xiangdong [4 ]
Zhi, Wei [1 ]
Weng, Jie [1 ]
Zhang, Kai [4 ]
Zhang, Xingdong [4 ]
机构：
[1] Southwest Jiaotong Univ, Coll Med, Sch Mat Sci & Engn, Key Lab Adv Technol Mat,Minist Educ, Chengdu 610031, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Sch Intelligent Med, Chengdu 611137, Peoples R China
[3] Sichuan Univ, Coll Basic & Forens Med, Dept Biochem & Mol Biol, Chengdu 610041, Peoples R China
[4] Sichuan Univ, Coll Biomed Engn, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
来源：
ADVANCED HEALTHCARE MATERIALS | 2023年 / 12卷 / 29期
基金：
中国国家自然科学基金;
关键词：
hemostasis; multifunctional biological adhesives; phenolic compounds; polyglutamic acid; tissue repairs; TISSUE ADHESIVE; HYDROGEL; ANTIOXIDANT; CEMENT; TAPE;
D O I：
10.1002/adhm.202301560
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The application of most hydrogel bio-adhesives is greatly limited due to their high swelling, low underwater adhesion, and single function. Herein, a spatial multi-level physical-chemical and bio-inspired in-situ bonding strategy is proposed, to develop a multifunctional hydrogel bio-glue using polyglutamic acid (PGA), tyramine hydrochloride (TYR), and tannic acid (TA) as precursors and 4-(4,6-dimethoxytriazine-2-yl) -4-methylmorpholine hydrochloride(DMTMM) as condensation agent, which is used for tissue adhesion, hemostasis and repair. By introducing TYR and TA into the PGA chain, it is demonstrated that not only can the strong adhesion of bio-glue to the surface of various fresh tissues and wet materials be realized through the synergistic effect of spatial multi-level physical and chemical bonding, but also this glue can be endowed with the functions of anti-oxidation and hemostasis. The excellent performance of such bio-glue in the repair of the wound, liver, and cartilage is achieved, showing a great potential in clinical application for such bio-glue. This study will open up a brand-new avenue for the development of multifunctional hydrogel biological adhesive.
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页数：14
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共 63 条
  • [11] Recent advances in wet adhesives: Adhesion mechanism, design principle and applications
    Cui, Chunyan
    Liu, Wenguang
    [J]. PROGRESS IN POLYMER SCIENCE, 2021, 116
  • [12] A Universal and Reversible Wet Adhesive via Straightforward Aqueous Self-Assembly of Polyethylenimine and Polyoxometalate
    Cui, Yuexin
    Yin, Liying
    Sun, Xiaoya
    Zhang, Ning
    Gao, Nan
    Zhu, Guangshan
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2021, 13 (39) : 47155 - 47162
  • [13] Underwater Adhesion of Multiresponsive Complex Coacervates
    Dompe, Marco
    Cedano-Serrano, Francisco J.
    Vahdati, Mehdi
    van Westerveld, Larissa
    Hourdet, Dominique
    Creton, Costantino
    van der Gucht, Jasper
    Kodger, Thomas
    Kamperman, Marleen
    [J]. ADVANCED MATERIALS INTERFACES, 2020, 7 (04):
  • [14] Bioinspired Underwater Adhesives
    Fan, Hailong
    Gong, Jian Ping
    [J]. ADVANCED MATERIALS, 2021, 33 (44)
  • [15] Barnacle Cement Proteins-Inspired Tough Hydrogels with Robust, Long-Lasting, and Repeatable Underwater Adhesion
    Fan, Hailong
    Wang, Jiahui
    Gong, Jian Ping
    [J]. ADVANCED FUNCTIONAL MATERIALS, 2021, 31 (11)
  • [16] A chitosan hydrogel sealant with self-contractile characteristic: From rapid and long-term hemorrhage control to wound closure and repair
    Fang, Wen
    Yang, Ling
    Hong, Liangjie
    Hu, Qiaoling
    [J]. CARBOHYDRATE POLYMERS, 2021, 271
  • [17] 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Toluene-4-sulfonate (DMT/NMM/TsO-) Universal Coupling Reagent for Synthesis in Solution
    Fraczyk, Justyna
    Kaminski, Zbigniew J.
    Katarzynska, Joanna
    Kolesinska, Beata
    [J]. HELVETICA CHIMICA ACTA, 2018, 101 (01)
  • [18] Plant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry
    Gan, Donglin
    Xing, Wensi
    Jiang, Lili
    Fang, Ju
    Zhao, Cancan
    Ren, Fuzeng
    Fang, Liming
    Wang, Kefeng
    Lu, Xiong
    [J]. NATURE COMMUNICATIONS, 2019, 10 (1)
  • [19] Nanostructured chitosan-surfactant matrices as polyphenols nanocapsules template with zero order release kinetics
    Garlea, Ana
    Melnig, V.
    Popa, M. I.
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2010, 21 (04) : 1211 - 1223
  • [20] Rapid self-healing, stretchable, moldable, antioxidant and antibacterial tannic acid-cellulose nanofibril composite hydrogels
    Ge, Wenjiao
    Cao, Shan
    Shen, Feng
    Wang, Yuyuan
    Ren, Junli
    Wang, Xiaohui
    [J]. CARBOHYDRATE POLYMERS, 2019, 224
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