Multifunctional Nanotheranostics for Dual-Modal Imaging-Guided Precision Therapy of Nasopharyngeal Carcinoma

Currently, the low survival rate and poor prognosis ofpatientswith nasopharyngeal carcinoma are ascribed to the lack of early andaccurate diagnosis and resistance to radiotherapy. In parallel, theintegration of imaging-guided diagnosis and precise treatment hasgained much attention in the field of theranostic nanotechnology.However, constructing dual-modal imaging-guided nanotheranostics withdesired imaging performance as well as great biocompatibility remainschallenging. Therefore, we developed a simple but multifunctionalnanotheranostic GdCPP for the early and accurate diagnosis and efficienttreatment of nasopharyngeal carcinoma (NPC), which combined fluorescenceimaging and magnetic resonance imaging (MRI) onto a single nanoplatformfor imaging-guided subsequent photodynamic therapy (PDT). GdCPP hadan appropriate particle size (81.93 & PLUSMN; 0.69 nm) and was highlystable, resulting in sufficient tumor accumulation, which along withmassive reactive oxygen species (ROS) generation upon irradiationfurther significantly killed tumor cells. Moreover, GdCPP owned muchstronger r (1) relaxivity (9.396 mM(-1) s(-1)) compared to clinically used Gd-DTPA (5.034mM(-1) s(-1)) and exhibited better T 1WI MRI performance. Under dual-modal imaging-guidedPDT, GdCPP achieved efficient therapeutic outcomes without causingany noticeable tissue damage. The results of in vitro and in vivo studies indicated that GdCPP may bea suitable candidate for dual-modal imaging-guided precision tumortherapy.