Chitosan-Based Composite Membranes with Different Biocompatible Metal Oxide Nanoparticles: Physicochemical Properties and Drug-Release Study

被引:3
作者
Baroudi, Alia [1 ,2 ]
Garcia-Payo, Carmen [1 ]
Khayet, Mohamed [1 ]
机构
[1] Univ Complutense Madrid, Fac Phys, Dept Struct Matter Thermal Phys & Elect, Avda Complutense s-n, Madrid 28040, Spain
[2] Univ Antonio Nebrija, Higher Polytech Sch, Dept Ind Engn, C-St cruz Marcenado 27, Madrid 28015, Spain
关键词
chitosan; metal oxide nanoparticle; swelling; mechanical properties; drug release; diffusion models; simulating gastrointestinal transit model; ACETYLSALICYLIC-ACID; FE3O4; NANOPARTICLES; TIO2; AQUEOUS-SOLUTIONS; ASPIRIN; NANOCOMPOSITES; SOLUBILITY; BEHAVIOR; REMOVAL; POLYMER;
D O I
10.3390/polym15132804
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Chitosan (CS) composite membranes were prepared using different biocompatible metal oxide nanoparticles (NPs): titanium dioxide (TiO2); iron oxide (Fe3O4); and aluminum oxide (Al2O3). For each nanoparticle, the CS-based composite membranes were prepared with two NPs contents in the CS solution, high (H) and low (L) NPs concentrations. To establish both concentrations, the NPs saturation point in the CS polymeric matrix was determined. The influence of NP concentrations on the physicochemical properties of the CS films was assessed. The prepared CS membranes were characterized with different techniques, such as X-ray diffraction (XRD), scanning electron microscopy (SEM), and zeta potential. It was found that the addition of NPs in the CS matrix improved both swelling and mechanical properties. Nanocomposite CS membranes could be prepared using Al2O3 NPs. Swelling experiments revealed different pH-sensitive mechanisms, which might be beneficial in biomedical applications since solute permeation through CS-based composite membranes could be controlled by adjusting environmental conditions. When aspirin transport (ASA) through the prepared membranes was carried out in different release media, SGF (simulating gastric fluid) and SIF (simulating intestinal fluid without enzymes), it was observed that the Fickian diffusion coefficient (D) was conditioned by the pH of the release solution. In SGIT (simulating gastrointestinal transit) medium, a transition time (t(trans)) was detected due to the shrinkage of the CS polymeric chains, and the drug release depended not only on the Fickian's diffusion but also on the shrinkage of the biopolymer, obeying Peppas and Sahlin equation.
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页数:25
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