Nickel-Catalyzed Reductive Three-Component Cross-Coupling of Butadiene with Aldehydes and Alkenyl Triflates/Bromides: Access to Skipped Dienes

被引：4

作者：

Xu, Yan ^{[1
]}

Su, Tong ^{[1
]}

Zhang, Jie-Rui ^{[1
]}

Ding, Hua-Jiao ^{[1
]}

Gao, Yuanji ^{[1
]}

Xu, Minghui ^{[1
]}

Cao, Peng ^{[1
]}

Hu, Ping ^{[1
]}

Wang, Bi-Qin ^{[1
]}

Chen, Bin ^{[1
]}

机构：

[1] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610068, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 17期

关键词：

1,3-DIENES; HALIDES; ACIDS;

D O I：

10.1021/acs.orglett.3c01036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A regio-and stereoselective nickel-catalyzed reductive three-component cross-coupling of 1,3-butadiene with aldehydes and alkenyl triflates or bromides was realized. This protocol afforded a convenient approach to the synthesis of skipped diene compounds bearing various functionals and heterocyclic groups. The utility of this reaction was also demonstrated by scale-up preparation and diverse transformations.

引用

页码：3136 / 3140

页数：5

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