First case report of multivisceral transplant from a deceased cardiac death donor

被引:5
作者
Andres, Ane M. [1 ,2 ,3 ,4 ]
Luis Encinas, Jose [1 ]
Sanchez-Galan, Alba [1 ]
Serradilla Rodriguez, Javier [1 ,2 ]
Estefania, Karla [1 ]
Gonzalez Sacristan, Rocio [5 ]
Alcolea, Alida [5 ]
Serrano, Pilar [5 ]
Estebanez, Belen [6 ,7 ]
Velasco Leon, Inigo [8 ,9 ]
Burgos, Paula [8 ,9 ]
Gonzalez Rocafort, Alvaro [9 ]
Ramchandani, Bunty [9 ]
Calderon, Belen [10 ]
Verdu, Cristina [10 ]
Jimenez, Esperanza [1 ,11 ]
Talayero, Paloma [12 ]
Stringa, Pablo [13 ]
de la Pena Navarro, Itziar [14 ]
Ramos, Esther
Hernandez Oliveros, Francisco [1 ,2 ,3 ]
机构
[1] La Paz Univ Hosp, Pediat Surg Dept, Madrid, Spain
[2] La Paz Univ Hosp, La Paz Res Inst Idipaz, Madrid, Spain
[3] European Reference Network Transplantat Children, Madrid, Spain
[4] Univ Autonoma Madrid, Anat Histol & Neurosci Dept, Madrid, Spain
[5] La Paz Univ Hosp, Pediat Gastroenterol Dept, Intestinal Rehabil Unit, Madrid, Spain
[6] La Paz Univ Hosp, Intens Care Unit, Madrid, Spain
[7] La Paz Univ Hosp, Transplant Coordinat Unit, Madrid, Spain
[8] La Paz Univ Hosp, Pediat Perfus Dept, Madrid, Spain
[9] La Paz Univ Hosp, Pediat Cardiovasc Surg Dept, Madrid, Spain
[10] La Paz Univ Hosp, Pediat Intens Care Unit Dept, Madrid, Spain
[11] La Paz Univ Hosp, Pediat Anesthesiol Dept, Madrid, Spain
[12] Hosp Univ 12 Octubre, Inst Invest Sanitaria Hosp Octubre 12 imas12, Immunol Dept, Madrid, Spain
[13] Natl Univ La Plata, Inst Immunol & Physiopathol Studies IIFP CONICET, Buenos Aires, Argentina
[14] La Paz Univ Hosp, Pathol Dept, Madrid, Spain
关键词
translational research; science; clinical research; practice; intestine; multivisceral transplantation; organ procurement and allocation; death (DCD); waitlist management; CIRCULATORY DEATH; DONATION; PERFUSION;
D O I
10.1016/j.ajt.2022.12.021
中图分类号
R61 [外科手术学];
学科分类号
摘要
The current shortage of pediatric multivisceral donors accounts for the long time and mortality on the waiting list of pediatric patients. The use of donors after cardiac death, especially after the outbreak of normothermic regional perfusion, has increased in recent years for all solid organs except the intestine, mainly because of its higher susceptibility to ischemia-reperfusion injury. We present the first literature case of multivisceral donors after cardiac death transplantation in a 13-month-old recipient from a 2.5-month-old donor. Once exitus was certified, an extracorporeal membrane oxygenation circuit was established, cannulating the aorta and infrarenal vena cava, while the supra-aortic branches were clamped. The abdominal organs completely recovered from ischemia through normothermic regional perfusion (extracorporeal membrane oxygenation initially and beating heart later). After perfusion with the preservation solution, the multivisceral graft was uneventfully implanted. Two months later, the patient was discharged without any complications. This case demonstrates the possibility of reducing the time spent on the waiting list for these patients.
引用
收藏
页码:577 / 581
页数:5
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