The genetic liability to rheumatoid arthritis may decrease hepatocellular carcinoma risk in East Asian population: a Mendelian randomization study

被引：6

作者：

Zhang, Yuzhuo ^{[1
]}

Zhang, Yudong ^{[2
,3
]}

He, Peng ^{[1
]}

Ge, Fan ^{[1
,4
]}

Huo, Zhenyu ^{[1
,4
]}

Qiao, Guibin ^{[5
,6
,7
]}

机构：

[1] Guangzhou Med Univ, Guangzhou 511436, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Thorac Surg, Guangzhou 510062, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Cardiothorac Surg East Div, Guangzhou 510062, Guangdong, Peoples R China

[4] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Natl Clin Res Ctr Canc, Beijing 100021, Peoples R China

[5] Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Thorac Surg, Guangzhou 510080, Guangdong, Peoples R China

[6] Shantou Univ, Med Coll, Shantou, Peoples R China

[7] Southern Med Univ, Sch Clin Med 2, Guangzhou 510515, Peoples R China

来源：

ARTHRITIS RESEARCH & THERAPY | 2023年 / 25卷 / 01期

关键词：

Rheumatoid arthritis; Hepatocellular carcinoma; Cancer risk; Genome-wide association study; Single nucleotide polymorphisms; Mendelian randomization; CANCER; INSTRUMENTS; MALIGNANCY; THERAPY; BIAS;

D O I：

10.1186/s13075-023-03029-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundPatients with rheumatoid arthritis (RA) have a rising possibility of acquiring certain kinds of cancers than the general public. The causal risk association between RA and hepatocellular carcinoma (HCC) remains unknown.MethodsGenetic summary data from genome-wide association study (GWAS), including RA (n = 19,190) and HCC (n = 197,611), was analyzed. The inverse-variance weighted (IVW) approach was used as the principal analysis, complemented with weighted median, weighted mode, simple median method, and MR-Egger analyses. The genetic data of RA (n = 212,453) was used to verify the results in eastern Asia populations.ResultsThe results from the IVW methods indicated that genetically predicted RA was significantly linked with a declined possibility of HCC for East Asians (OR = 0.86; 95% CI: 0.78, 0.95; p = 0.003). The weighted median and the weighted mode also supported similar results (all p < 0.05). Additionally, neither the funnel plots nor the MR-Egger intercepts revealed any directional pleiotropic effects between RA and HCC. Moreover, the other set of RA data validated the results.ConclusionThe RA may decrease the risk of being susceptible to the HCC in eastern Asia populations, which was beyond expectation. In the future, additional investigations should be made into potential biomedical mechanisms.

引用

页数：9