Comparison of Target Pocket Similarity and Progress into Research on Inhibitors of Picornavirus 3C Proteases

被引：1

作者：

Wan, Li ^{[1
]}

Wang, Xiaobo ^{[2
]}

Wang, Tangle ^{[1
]}

Yuan, Xiaolan ^{[1
]}

Liu, Wei ^{[1
]}

Huang, Yan ^{[1
]}

Deng, Changyong ^{[1
]}

Cao, Shuang ^{[1
]}

机构：

[1] Wuhan Inst Technol, Minist Educ, Sch Chem Engn & Pharm, Key Lab Green Chem Engn Proc, Wuhan 430205, Peoples R China

[2] Hubei Univ Sci & Technol, Xianning Med Coll, Sch Pharm, Xianning 437100, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 03期

关键词：

3C protease; similarity of target pockets; 3C protease inhibitors; STRUCTURE-BASED DESIGN; ENTEROVIRUS; 71; BIOLOGICAL EVALUATION; ANTIVIRAL ACTIVITY; IRREVERSIBLE INHIBITORS; SUBSTITUTED FLAVANOIDS; ISATIN DERIVATIVES; 3C-LIKE PROTEASES; STRUCTURAL BASIS; MAIN PROTEASE;

D O I：

10.1002/cbdv.202201100

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 3C protease (3C Pro) plays a significant role in the life cycle of picornaviruses from replication to translation, making it an attractive target for structure-based design of drugs against picornaviruses. The structurally related 3C-like protease (3CL Pro) is an important protein involved in the replication of coronaviruses. With the emergence of COVID-19 and consequent intensive research into 3CL Pro, development of 3CL Pro inhibitors has emerged as a popular topic. This article compares the similarities of the target pockets of various 3C and 3CL Pros from numerous pathogenic viruses. This article also reports several types of 3C Pro inhibitors that are currently undergoing extensive studies and introduces various structural modifications of 3C Pro inhibitors to provide a reference for the development of new and more effective inhibitors of 3C Pro and 3CL Pro.

引用

页数：24