Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy

被引：38

作者：

Fabozzi, Antonio ^{[1
,2
]}

Della Sala, Francesca ^{[1
]}

di Gennaro, Mario ^{[1
,4
]}

Barretta, Marco ^{[1
]}

Longobardo, Gennaro ^{[1
,3
]}

Solimando, Nicola ^{[2
]}

Pagliuca, Maurizio ^{[2
]}

Borzacchiello, Assunta ^{[1
]}

机构：

[1] CNR, Inst Polymers Composites & Biomat, IPCB CNR, Naples, Italy

[2] ALTERGON ITALIA Srl, Zona Ind ASI, I-83040 Morra De Sanctis, AV, Italy

[3] Univ Naples Federico II, Dept Chem Mat & Ind Engn, Ple Tecchio 80, I-80125 Naples, Italy

[4] Univ Campania L Vanvitelli, Dept Environm Biol & Pharmaceut Sci & Technol DiST, I-81100 Caserta, Italy

来源：

LAB ON A CHIP | 2023年 / 23卷 / 05期

关键词：

SOLID LIPID NANOPARTICLES; CONTINUOUS-FLOW SYNTHESIS; INORGANIC NANOPARTICLES; MAGNETIC HYPERTHERMIA; HYBRID NANOPARTICLES; MESSENGER-RNA; IN-VITRO; SIRNA; DOXORUBICIN; CARRIERS;

D O I：

10.1039/d2lc00933a

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Nanoparticle systems are functional carriers that can be used in the cancer therapy field for the delivery of a variety of hydrophobic and/or hydrophilic drugs. Recently, the advent of microfluidic platforms represents an advanced approach to the development of new nanoparticle-based drug delivery systems. Particularly, microfluidics can simplify the design of new nanoparticle-based systems with tunable physicochemical properties such as size, size distribution and morphology, ensuring high batch-to-batch reproducibility and consequently, an enhanced therapeutic effect in vitro and in vivo. In this perspective, we present accurate state-of-the-art microfluidic platforms focusing on the fabrication of polymer-based, lipid-based, lipid/polymer-based, inorganic-based and metal-based nanoparticles for biomedical applications.

引用

页码：1389 / 1409

页数：21