Cartilage calcification in osteoarthritis: mechanisms and clinical relevance

被引：82

作者：

Bernabei, Ilaria ^{[1
]}

So, Alexander ^{[1
]}

Busso, Nathalie ^{[1
]}

Nasi, Sonia ^{[1
]}

机构：

[1] Univ Lausanne, Lausanne Univ Hosp, Dept Musculoskeletal Med, Serv Rheumatol, Lausanne, Switzerland

来源：

NATURE REVIEWS RHEUMATOLOGY | 2023年 / 19卷 / 01期

关键词：

BASIC CALCIUM-PHOSPHATE; PROTEIN-KINASE-C; NITRIC-OXIDE SYNTHASE; GLA-RICH PROTEIN; PYROPHOSPHATE DIHYDRATE CRYSTALS; FACTOR-KAPPA-B; ARTICULAR-CARTILAGE; SYNOVIAL-FLUID; BONE SIALOPROTEIN; HUMAN FIBROBLASTS;

D O I：

10.1038/s41584-022-00875-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be observed both at the cartilage surface and in its deeper layers. The formation of calcium-containing crystals, typically basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate (CPP) crystals, is an active, highly regulated and complex biological process that is initiated by chondrocytes and modified by genetic factors, dysregulated mitophagy or apoptosis, inflammation and the activation of specific cellular-signalling pathways. The links between OA and BCP deposition are stronger than those observed between OA and CPP deposition. Here, we review the molecular processes involved in cartilage calcification in OA and summarize the effects of calcium crystals on chondrocytes, synovial fibroblasts, macrophages and bone cells. Finally, we highlight therapeutic pathways leading to decreased joint calcification and potential new drugs that could treat not only OA but also other diseases associated with pathological calcification.

引用

页码：10 / 27

页数：18

共 264 条

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