Harnessing potent therapies with care: enfortumab vedotin plus pembrolizumab for advanced-stage urothelial carcinoma

被引：3

作者：

Ghatalia, Pooja ^{[1
]}

Plimack, Elizabeth R. ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Dept Hematol & Oncol, Philadelphia, PA 19111 USA

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2023年 / 20卷 / 12期

关键词：

CISPLATIN; CHEMOTHERAPY; CANCER; UNFIT;

D O I：

10.1038/s41571-023-00814-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Following the recent FDA Accelerated Approval of enfortumab vedotin (EV) plus pembrolizumab for patients with advanced-stage urothelial carcinoma who are cisplatin-ineligible, herein we highlight key clinical outcomes with this combination based on results from Cohort K of the pivotal phase Ib/II EV-103 trial. We also discuss treatment sequencing, de-escalation strategies and toxicity management as EV-pembrolizumab becomes widely used in clinical practice.

引用

页码：818 / 819

页数：2

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