Reshaping tumor immune microenvironment by Epstein-Barr virus activation in the stroma of colorectal cancer

被引：1

作者：

Park, Hyun Ju ^{[1
]}

Cho, Eun Jeong ^{[2
]}

Kim, Ji-Hun ^{[1
]}

Lim, Sehun ^{[3
]}

Sung, Chang Ohk ^{[1
,2
]}

机构：

[1] Univ Ulsan, Asan Med Ctr, Dept Pathol, Coll Med, 88 Olymp Ro 43 Gil, Seoul, South Korea

[2] Univ Ulsan, Asan Med Inst Convergence Sci & Technol, Asan Med Ctr, Dept Med Sci,Coll Med, Seoul, South Korea

[3] Inje Univ, Busan Paik Hosp, Dept Anesthesiol & Pain Med, Coll Med, Pusan, South Korea

来源：

ISCIENCE | 2023年 / 26卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Cancer; Immunology; Microenvironment;

D O I：

10.1016/j.isci.2022.105919

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The formation of tumor immune microenvironment (TIM) is complicated and poorly understood. Little is known about the effect of a viral infection potentially inducing an additional immune response in the TIM. Here, we identify Epstein -Barr virus (EBV) expression in the TIM in colorectal cancer (CRC) tissue through EBV-encoded RNA in-situ hybridization and RNA sequencing data and investigate the effects of EBV on TIM composition and clinical outcomes. EBV was detected in tumor-infiltrating lymphocytes, but not in cancer cells. EBV positivity was associ-ated with older age, male sex, and SMAD4 mutations. EBV-positive tumors were characterized by enrichment in chemokine/cytokine signaling pathways and altered immune cell composition, including plasma and CD4 T cells, as well as can-cer cells intrinsically enriched pathways related to immune tolerance, leading to poor prognosis. In conclusion, we identified EBV expression in TIM and suggested its association with poor prognosis by altering the TIM in CRC.

引用

页数：14

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