Building Natural Product-Based Libraries for Drug Discovery: Challenges and Opportunities from a Brazilian Pharmaceutical Industry Perspective

被引：6
作者：
Conrado, Gabrielly Galdino [1 ,2 ]
da Rosa, Rafael [2 ]
Reis, Romulo Dragani [2 ]
Pessa, Lisandra Ravanelli [2 ]
机构：
[1] Inst Euvaldo Lodi, Sao Paulo, SP, Brazil
[2] Ache Labs Farmaceut, Guarulhos, SP, Brazil
来源：
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2024年 / 34卷 / 04期
关键词：
Crude extract libraries; Natural products; Pre-fractionated libraries; Drug discovery; Analytical techniques; Pharmaceutical industry; ESSENTIAL OIL CONTENT; DRYING METHODS; QUANTITATIVE PROPERTIES; EXTRACTION; SOLVENT; BIODIVERSITY; TECHNOLOGY; CULTURES;
D O I：
10.1007/s43450-024-00540-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Natural products represent an important source of new leads in drug discovery research. Several drugs currently used as therapeutic agents have been developed from natural sources, bioactive crude extracts and their plant secondary metabolites being specifically important. The screening of natural products can provide greater structural diversity than standard synthetic chemistry and offer significant opportunities for finding novel low molecular weight lead compounds. However, research with natural products also presents challenges for drug discovery, such as access and use of biological resources, technical barriers to screening, isolation, characterization, and resupply. Therefore, different strategies are presented as possible for a natural product-based drug discovery process. This review leads the reader through the main processes necessary to develop a modern natural product-based drug discovery program by summarizing the methods and strategies used to assemble and manage natural product libraries of plant origin. In addition, it brings insightful comments from a pharmaceutical industry perspective and presents original content, such as a curation of commercially available natural product libraries.
引用
收藏
页码：706 / 721
页数：16
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