Hydrogels in Gene Delivery Techniques for Regenerative Medicine and Tissue Engineering

被引：2

作者：

Xu, Kexing ^{[1
]}

Zhang, Qinmeng ^{[1
,2
]}

Zhu, Danji ^{[1
,2
]}

Jiang, Zhiwei ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Sch Med, Hangzhou, Peoples R China

[2] Zhejiang Univ, Canc Ctr, Engn Res Ctr Oral Biomat & Devices Zhejiang Prov, Key Lab Oral Biomed Res Zhejiang Prov,Stomatol Hos, Hangzhou 310000, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2024年 / 24卷 / 06期

基金：

中国国家自然科学基金;

关键词：

bioink; gene delivery; hydrogels; regenerative medicine; tissue engineering; MESENCHYMAL STEM-CELLS; DRUG-DELIVERY; EXTRACELLULAR VESICLES; CONTROLLED-RELEASE; THERMOSENSITIVE HYDROGEL; BONE REGENERATION; WOUND MANAGEMENT; HYALURONIC-ACID; CROSS-LINKING; RAAV VECTORS;

D O I：

10.1002/mabi.202300577

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrogels are 3D networks swollen with water. They are biocompatible, strong, and moldable and are emerging as a promising biomedical material for regenerative medicine and tissue engineering to deliver therapeutic genes. The excellent natural extracellular matrix simulation properties of hydrogels enable them to be co-cultured with cells or enhance the expression of viral or non-viral vectors. Its biocompatibility, high strength, and degradation performance also make the action process of carriers in tissues more ideal, making it an ideal biomedical material. It has been shown that hydrogel-based gene delivery technologies have the potential to play therapy-relevant roles in organs such as bone, cartilage, nerve, skin, reproductive organs, and liver in animal experiments and preclinical trials. This paper reviews recent articles on hydrogels in gene delivery and explains the manufacture, applications, developmental timeline, limitations, and future directions of hydrogel-based gene delivery techniques.

引用

页数：26

共 258 条

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