Efficacy and Safety of Upadacitinib in the Treatment of Chronic Pouchitis, Cuffitis, and Crohn's Disease of the Pouch

被引：10

作者：

Lan, Nan ^{[1
]}

Shen, Bo ^{[2
]}

机构：

[1] Columbia Univ, New York Presbyterian Hosp, Irving Med Ctr, Div Digest & Liver Dis, New York, NY USA

[2] Columbia Univ, New York Presbyterian Hosp, Ctr Inflammatory Bowel Dis, Irving Med Ctr, New York, NY 10027 USA

来源：

ACG CASE REPORTS JOURNAL | 2024年 / 11卷 / 01期

关键词：

Crohn's disease; cuffitis; pouchitis; upadacitinib; MANAGEMENT;

D O I：

10.14309/crj.0000000000001245

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Upadacitinib has shown efficacy in the treatment of moderate-to-severe ulcerative colitis and Crohn's disease (CD). The use of upadacitinib in the treatment of chronic antibiotics-refractory pouchitis (CARP), as well as CD of the pouch, has not been previously reported. We treated a series of 6 patients with CARP or CD of the pouch with a minimal 6 weeks of upadacitinib. The patients showed minimal or no significant improvement in clinical and endoscopic presentations. Our findings warrant further study to validate the efficacy and safety of upadacitinib in the treatment of CARP or CD of the pouch.

引用

页数：4

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