Visible-Light-Induced Regioselective Radical Oxo-Amination of Alkenes with O2 as the Oxygen Source

被引:7
作者
Wang, Jiayang [1 ]
Shao, Baoer [2 ]
Ge, Haixia [1 ]
Li, Yongjin [1 ]
Qi, Huan [1 ]
Xiao, Li [1 ]
机构
[1] Huzhou Univ, Sch Life Sci, Huzhou 313002, Zhejiang, Peoples R China
[2] YuYao Peoples Hosp Zhejiang Prov, Yuyao 315400, Zhejiang, Peoples R China
关键词
ONE-POT SYNTHESIS; KETONES; DIFUNCTIONALIZATION; ENERGY; ALKOXY;
D O I
10.1021/acs.orglett.3c01910
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient and novel visible-light-inducedoxo-amination of terminalalkenes for the construction of & alpha;-amino ketones with easilyaccessible and green O-2 as the oxygen source has been developed.The transformation possesses the advantages of operational simplicity,a broad substrate scope, high atom economy, and mild reaction conditions.The mechanistic studies reveal that an energy transfer process probablyoccurs in the initial stage, and the reaction proceeds via & beta;-scissionof the alkoxyl radical species.
引用
收藏
页码:5333 / 5338
页数:6
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