Exercise elevates serum brain-derived neurotrophic factor in partially remitted depression

被引：6

作者：

Kramer, Benedikt Alexander ^{[1
]}

Jaehn, Anna ^{[1
]}

Gruetzner, Thea Marianne ^{[1
]}

Hess, Natalie Sarah ^{[1
]}

Bellanti, Amanda ^{[1
]}

Listunova, Lena ^{[1
]}

Hellweg, Rainer ^{[2
,3
,4
]}

Weisbrod, Matthias ^{[1
,5
]}

Ely, Daniela Roesch ^{[1
]}

机构：

[1] Univ Hosp Heidelberg, Ctr Psychosocial Med, Dept Gen Psychiat, Res Grp Neurocognit, Vossstr 4, D-69115 Heidelberg, Germany

[2] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

[3] Humboldt Univ, Freie Univ Berlin, Berlin, Germany

[4] Berlin Inst Hlth, Berlin, Germany

[5] SRH Hosp Karlsbad Langensteinbach, Dept Psychiat & Psychotherapy, Guttmannstr 1, D-76307 Karlsbad, Germany

来源：

PSYCHIATRY RESEARCH | 2023年 / 326卷

关键词：

Physical activity; Blood serum; Biomarkers; BDNF;

D O I：

10.1016/j.psychres.2023.115283

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine implicated in the pathogenesis of major depressive disorder (MDD). In MDD, serum BDNF levels are attenuated. Healthy adults show BDNF elevation after exercise. To investigate activity-dependent BDNF elevation in MDD, thirty-seven participants with partially remitted MDD were allocated to either a bout of strenuous or light activity. Serum was collected before and after the intervention. BDNF was measured using a highly sensitive and specific enzyme-linked immunosorbent assay. Significant BDNF elevation in the strenuous activity group emerged. This study confirms exercise-dependent serum BDNF elevation in MDD. Preregistration: German Clinical Trials Register (DRKS0001515).

引用

页数：3

共 16 条

[1]

BORG G, 1970, Scandinavian Journal of Rehabilitation Medicine, V2, P92

[2] Exercise for depression [J].

Cooney, Gary M. ;

Dwan, Kerry ;

Greig, Carolyn A. ;

Lawlor, Debbie A. ;

Rimer, Jane ;

Waugh, Fiona R. ;

McMurdo, Marion ;

Mead, Gillian E. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2013, (09)

[3] A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists [J].

Duman, Ronald S. ;

Li, Nanxin .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2012, 367 (1601) :2475-2484

[4] USING PSYCHOMETRIC TECHNIQUES TO IMPROVE THE BALANCE EVALUATION SYSTEMS TEST: THE MINI-BESTEST [J].

Franchignoni, Franco ;

Horak, Fay ;

Godi, Marco ;

Nardone, Antonio ;

Giordano, Andrea .

JOURNAL OF REHABILITATION MEDICINE, 2010, 42 (04) :323-331

[5] A RATING SCALE FOR DEPRESSION [J].

HAMILTON, M .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1960, 23 (01) :56-62

[6] Effect of acute psychosocial stress on the brain-derived neurotrophic factor in humans - a randomized cross within trial [J].

Hermann, Robin ;

Schaller, Andrea ;

Lay, Daniel ;

Bloch, Wilhelm ;

Albus, Christian ;

Petrowski, Katja .

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 2021, 24 (04) :442-449

[7] Serum brain-derived neurotrophic factor (BDNF) at rest and after acute aerobic exercise in major depressive disorder [J].

Kallies, Gunnar ;

Rapp, Michael A. ;

Fydrich, Thomas ;

Fehm, Lydia ;

Tschorn, Mira ;

Teran, Christina ;

Schwefel, Melanie ;

Pietrek, Anou ;

Henze, Romy ;

Hellweg, Rainer ;

Stroehle, Andreas ;

Heinzel, Stephan ;

Heissel, Andreas .

PSYCHONEUROENDOCRINOLOGY, 2019, 102 :212-215

[8] Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity [J].

Kandola, Aaron ;

Ashdown-Franks, Garcia ;

Hendrikse, Joshua ;

Sabiston, Catherine M. ;

Stubbs, Brendon .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2019, 107 :525-539

[9] Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression [J].

Laske, Christoph ;

Banschbach, Sabine ;

Stransky, Elke ;

Bosch, Sabine ;

Straten, Guido ;

Machann, Juergen ;

Fritsche, Andreas ;

Hipp, Arno ;

Niess, Andreas ;

Eschweiler, Gerhard W. .

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2010, 13 (05) :595-602

[10] Relationships between serum BDNF and the antidepressant effect of acute exercise in depressed women [J].

Meyer, Jacob D. ;

Koltyn, Kelli F. ;

Stegner, Aaron J. ;

Kim, Jee-Seon ;

Cook, Dane B. .

PSYCHONEUROENDOCRINOLOGY, 2016, 74 :286-294

← 1 2 →