Ferroptosis: A potential therapeutic target in autoimmune disease (Review)

被引：15
作者：
Shen, Liang [1 ]
Wang, Xiaohan [2 ]
Zhai, Changlin [1 ]
Chen, Yunqing [3 ,4 ]
机构：
[1] Jiaxing Univ, Affiliated Hosp, Dept Cardiol, Jiaxing 314000, Zhejiang, Peoples R China
[2] Jiaxing Univ, Affiliated Hosp, Dept Gastroenterol, Jiaxing 314000, Zhejiang, Peoples R China
[3] Jiaxing Univ, Affiliated Hosp, Dept Infect Dis, Jiaxing 314000, Zhejiang, Peoples R China
[4] Jiaxing Univ, Dept Infect Dis, Affiliated Hosp, 1882 Zhonghuan South Rd, Jiaxing 314000, Zhejiang, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2023年 / 26卷 / 02期
关键词：
ferroptosis; autoimmune disease; immune system; therapeutic target; SYSTEMIC-LUPUS-ERYTHEMATOSUS; DOUBLE-BLIND; PARKINSONS-DISEASE; ULCERATIVE-COLITIS; LIPID-PEROXIDATION; CELL-DEATH; VITAMIN-E; T-CELLS; SELENIUM SUPPLEMENTATION; RHEUMATOLOGY GUIDELINE;
D O I：
10.3892/etm.2023.12067
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Ferroptosis is a distinct type of regulated cell death characterized by iron overload and lipid peroxidation. Ferroptosis is regulated by numerous factors and controlled by several mechanisms. This cell death type has a relationship with the immune system, which may be regulated by damage-associated molecular patterns. Ferroptosis participates in the progression of autoimmune diseases, including autoimmune hepatitis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, multiple sclerosis, Parkinson's Disease, psoriasis and insulin-dependent diabetes mellitus. The present review summarizes the role of ferroptosis in autoimmune disorders and discusses ferroptosis as a potential therapeutic target for autoimmune disease.
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页数：9
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